Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

By Robert Schneider, Andrew J. Bannister, F. Myers, A. Thorne, C. Crane-Robinson, Tony Kouzarides. Nature Cell Biology, 2004

819 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1bd7975ff0bea8c602d6d6501935dc6e9874942c

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Citations in the corpus

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling (2006, methodology): “Chromatin was isolated from either Flag– BPTF-expressing (þ) or non-expressing (2) HEK293 cells and solubilized with micrococcal nuclease.”
Elongation by RNA polymerase II: the short and long of it. (2004, background): “In mammals, both di- and trimethylated H3-K4 are associated with euchromatic regions, but whereas high levels of trimethyl H3-K4 are exclusively 2450 GENES & DEVELOPMENT located on active genes, dimethyl H3-K4 has been associated with silenced regions as well (Schneider et al. 2004).”
Epigenetic regulation of gene responsiveness in Arabidopsis (2014, background): “H3K4me3 is a prominent histone mark that is associated with gene promoters in many eukaryotes (Schneider et al., 2004; Vermeulen and Timmers, 2010).”
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007, background): “H3K4 trimethylation (H3K4me3) is tightly associated with the transcription start site at the 50 end of active genes (Bernstein et al., 2005; Schneider et al., 2004).”
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal (2008, neutral): “As trimethyl-K4-H3 defines chromatin regions that are permissive for transcriptio”
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). (2005, background): “A number of these transcriptionally “poised” regions have been described for the globin genes (Gross and Garrard 1988; Hebbes et al. 1992; Schneider et al. 2004).”
A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “Previous studies have emphasized that nucleosomes with histone H3K4me3 are associated with actively transcribed genes in various eukaryotes (Bernstein et al., 2002; Santos-Rosa et al., 2002; Ng et al., 2003; Schneider et al., 2004; Schubeler et al., 2004; Pokholok et al., 2005).”
Gene regulation by the act of long non-coding RNA transcription (2013, background): “For example, in yeast the SET1/2 methyltransferases, which induce H3K4me2 and H3K36me3 in the body of transcribed genes, bind and travel with elongating RNAPII [58-60].”
A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5′ flanking region of SMYD3 is a risk factor for human cancers (2005, background): “Methylation of H3 Lys4 is frequently observed in transcriptionally active regions of the human genome; trimethylation of H3 Lys4 changes the chromatin structure, leading to transactivation of target gene”
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. (2004, background): “However, a recent analysis in chicken erythrocytes did not reveal such difference in the presence of di- and trimethylation of this residue; instead, di- and trimethylation seemed to peak at the same sequences (Schneider et al. 2004).”