Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.

By G. Gallina, L. Dolcetti, P. Serafini, Carmela De Santo, Ilaria Marigo, M. Colombo, G. Basso, F. Brombacher, I. Borrello, Paola Zanovello and 2 more. Journal of Clinical Investigation, 2006

897 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/00934c1279c33d492a3468384c689e1df1ecdadd

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In Immunology

Citations in the corpus

Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. (2010, methodology): “Moreover, we also provided evidence indicating that mouse and human MDSCs can be generated through a simple, short-term culture system by a combination of cytokines that are normally released under inflammatory conditions but are also present in tumor microenvironment, further confirming the link be”
Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “Interestingly, both IL-4- and IFNγ-mediated signalling have been implicated in MDSC function, and the co-expression of arginase 1 and NOS2 seems to be required for immunosuppressive activit”
Myeloid-derived suppressor cell heterogeneity and subset definition. (2010, background): “The elusive Gr-1 molecule Anti-Gr-1 mAb (RB6-8C5) has long been used to stain MDSCs and allows the distinction of at least two cellular fractions according to its brightness: a Gr-1, mainly composed of immature and mature granulocytes, and a Gr-1, comprising monocytes and other immature myeloid cell”
Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice (2008, background): “It has been previously reported that CD11b cells expressing MCSF receptor (CD115) or IL-4R (CD124) had potent immunosuppressive activity (22, 23).”
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. (2008, background): “20 In the present study, NO most likely mediates suppression, as indicated by (1) the significantly enhanced NO2 concentrations in the supernatant, (2) the inability of an arginase inhibitor to further enhance the effect of L-NMMA, and (3) the inability of superoxide dismutase or catalase to diminis”
Developmental and Functional Heterogeneity of Monocytes. (2018, background): “The addition of further cell surface markers unmasked the presence of monocytic and polymorphonuclear MDSC and allowed the independent analysis of both subsets (Bronte et al., 2016; Gallina et al., 2006; Huang et al., 2006; Movahedi et al., 2008).”
Arginase: an emerging key player in the mammalian immune system (2009, background): “MDSC can suppress T cell immune functions by constitutive expression of arginase with consecutive L-arginine depletion (Bronte et al., 2003; Liu et al., 2003; Kusmartsev et al., 2004; Rodriguez et al., 2004; Sinha et al., 2005; Gallina et al., 2006; Serafini et al., 2006b).”
Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase (2008, background): “This might be especially valuable for a deeper understanding of tumour-host interactions, as it is increasingly appreciated that tumours build up a specific microenvironment that affects crucially host immune response and cancer cell proliferation and dissemination [4,5].”
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “These so-called “MDSCs” (53) have also been associated with other cell surface markers such as IL-4R (35, 54), F4/80 (35, 37, 55), CD80 (56), Ly6C, and Ly6G (37).”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “The -chain of the receptor for IL-4 and IL-13 (IL-4R ) (34, 35), another macrophage marker (F4/ 80) (34, 36, 37), M-CSF-1R or c-fms (CD115) (37), and the costimulatory molecule CD80 (B7.”