Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.

By K. Movahedi, M. Guilliams, J. van den Bossche, R. Van den Bergh, C. Gysemans, A. Beschin, P. De Baetselier, J. V. Van Ginderachter. Blood, 2008

1,331 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/4a23f85c96f78751a9cfe3a4305c4bcc54bdfd1a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “It is remarkable and intriguing that cells with the very same phenotype, expressing CD115, Gr1, and CD11b, also expand in the spleen of a tumor-bearing host (138, 139).”
TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression (2010, background): “Both populations suppress antigen-specific T-cell responses, but by distinct effector molecules and signaling pathways [52].”
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. (2010, methodology): “We and others have previously shown that splenic CD11b + Gr-1 + MDSCs consist of two major subsets: monocytic Ly6G − MO-MDSCs and granulocytic Ly6G + PMN-MDSCs (19, 47).”
Tumor-associated neutrophils: friend or foe? (2012, neutral): “TAMs [12,93].”
The role of myeloid cells in the promotion of tumour angiogenesis (2008, background): “However, unlike murine neutrophils, which also express CD11b and Gr1 (also known as LY6G and LY6C), MDSC can be broadly grouped into two subfractions: those that are CD11b + Gr1 hi , which have an immature neutrophil phenotype, and those that are CD11b + Gr1 low , which resemble monocyte”
Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice (2008, methodology): “This tumor was precisely the type used in a previous study (33).”
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “In addition to cell surface markers, MDSC have been characterized by their content of suppressive molecules including arginase (10, 57, 58), iNOS (59), and other reactive oxygen species (58, 60), and have been classified as “neutrophil-like” or “monocyte-like” based on their nuclear morphology (38).”
Modulation of the anti-tumor immune response by complement (2008, background): “These subpopulations corresponded to mononuclear MDSCs (MO-MDSCs) and polymorphonuclear MDSCs (PMN-MDSCs), which have been described befor”
Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. (2015, background): “The Gr-1 marker is not a singular molecule, but instead is a combination of the Ly6C and Ly6G markers, and these subsets can be more accurately identified based on Ly6C and Ly6G markers (M-MDSC as CD11b+Ly6ChiLy6G– and PMNMDSC as CD11b+Ly6CloLy6G+) (4, 5).”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Both monocytic MDSC (CD11b Ly6G Ly6C) and granulocytic MDSC were reported to be IFN- dependent; however, monocytic MDSC suppress via NO (ROS undetectable), whereas granulocytic MDSC suppress via ROS (NO undetectable) (39, 41).”