Arginase: an emerging key player in the mammalian immune system

By M. Munder. British Journal of Pharmacology, 2009

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The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses (2020, background): “Indeed, L-arginine depletion by arginase is culminated in the downregulation of the TCR ζ chain (66).”
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms (2015, background): “Initial studies on the function of macrophage arginase-1 have emphasized that L-ornithine may enter polyamine and collagen biosynthesis, eventually promoting fibrosis and tissue healing [35].”
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “One of the best characterized markers is the enzyme arginase 1 (Arg1) [25], which converts arginine to polyamines, proline, and ornithines that can contribute to wound healing and matrix deposition [26].”
Overview of General and Discriminating Markers of Differential Microglia Phenotypes (2020, background): “ARG1 is an enzyme converting an amino acid arginine into ornithine and urea, further metabolized to proline and polyamides needed for wound healing or tissue remodeling (Hesse et al., 2001; Munder et al., 2005; Munder, 2009; Quirié et al., 2013).”