Developmental and Functional Heterogeneity of Monocytes.
By M. Guilliams, A. Mildner, S. Yona. Immunity, 2018
809 citations recorded by the source corpus.
Novel experimental approaches such as fate-mapping and single-cell analysis have brought fresh insight into monocyte development and function over the past decade and helped redefine the monocyte field. Monocytes are now known to consist of multiple subsets generated through distinct developmental pathways with diverse functional specializations. Their fates under homeostatic conditions include the accumulation in peripheral reservoirs and the engraftment into certain resident macrophage pools. Under pathological conditions, monocytes acquire inflammatory effector functions, but can also develop regulatory properties essential for tissue repair. Importantly, monocytes recruited during inflammation are often functionally distinct from resident macrophages or conventional dendritic cells. Here we outline emerging concepts in monocyte heterogeneity, emergency monopoiesis, and trained immunity and discuss how these bring new perspectives to monocyte research.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/85845c77658670c31be1788a3aa6042447cd0dc4
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In Immunology
Citations in the corpus
- Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 (2020, neutral): “UMAP visualization of monocytes analyzed by scRNA-seq identified three clusters (Figure 3A) that may correspond to well-defined monocyte subsets (Guilliams et al., 2018).”
- The role of macrophages in the resolution of inflammation. (2019, methodology): “We join other authors who suggest strictly limiting the use of M1/M2 polarization to the well-defined in vitro conditions in which it was described (46, 47).”
- Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases (2019, background): “Based on evidence originating from murine studies [reviewed in (1, 27)], but also recent human observations (28), it is now widely accepted that classical monocytes have the ability to differentiate into monocytederived macrophages (moMφs) and DCs (moDCs) (29) and play an integral part in shaping in”