Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor.

By Ilaria Marigo, E. Bosio, S. Solito, C. Mesa, Audry Fernández, L. Dolcetti, S. Ugel, N. Sonda, S. Bicciato, Erika Falisi and 6 more. Immunity, 2010

894 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/c301eb9980d271c45595a898d553b466ad0e6e58

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Gabrilovich
2. M. Pittet
3. V. Bronte
4. D. Marvel
5. Zena Werb
6. Matthias Nahrendorf
7. A. Mildner
8. Hugo Gonzalez

In Oncology

1. D. Gabrilovich
2. V. Bronte
3. Hugo Gonzalez
4. D. Bar-Sagi
5. Y. Pylayeva-Gupta
6. Kyoung Eun Lee
7. A. Mildner
8. G. Miller

Citations in the corpus

• Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. (2015, background): “The effect of STAT3 on MDSC accumulation and suppressive function was found to be mediated by C/EBP β (55) and IFN regulatory factor-8 (IRF8) (61, 62).”
• Myeloid-derived suppressor cells (2017, background): “Induction of antigen-specific T-cell tolerance is one of the major characteristics of these cells (11, 12).”
• Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “The presence of PMN-MDSCs in tumors is associated with induction of chronic inflammation and antigen-specific tolerance by T cells (Marigo et al. 2010).”
• Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells (2011, background): “Despite being one of the most frequently investigated chemokines in tumor immunology, the role of CCL2 in tumor immunity remains unclear, and several conflicting studies have been published (Rollins and Sunday, 1991; Bottazzi et al., 1992; Fridlender et al., 2010).”
• Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia (2012, background): “A similar consequential relationship between GM-CSF generation and Gr1+CD11b+ cell expansion has been documented in other Cancer Cell 21, 836–847, June 12, 2012 ª2012 Elsevier Inc. 843 tumor models (Dolcetti et al., 2010; Marigo et al., 2010; Morales et al., 2010).”
• Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “C/EBPβ has also been shown to be required for the development of myeloid-derived suppressor cells (MDSCs) in mice grafted with tumour cell”
• Origins of tumor-associated macrophages and neutrophils (2012, background): “GM-CSF and other factors control the mobilization of bone marrow HSCs to the periphery and should next be investigated for their roles in extramedullary hematopoietic responses.”