J. Engelman
Oncology · 2006–2017
A researcher in the Science corpus: 33 papers; trusts 17 researchers and is trusted by 15 researchers here, as inferred from the citation graph.
Subfields
- Oncology — 376 citations into it
- Molecular Biology — 311 citations into it; #2,852 of 17,773 by trust here, #838 by citations
- Pulmonary and Respiratory Medicine — 275 citations into it; #59 of 770 by trust here, #9 by citations
- Genetics — 74 citations into it
- Pathology and Forensic Medicine — 58 citations into it; #40 of 414 by trust here, #31 by citations
- Radiology, Nuclear Medicine and Imaging — 30 citations into it; #1,774 of 3,265 by trust here, #2,673 by citations
- Surgery — 22 citations into it
- Cell Biology — 18 citations into it; #1,146 of 2,073 by trust here, #464 by citations
Whom J. Engelman trusts overall
Their strongest outbound trust, strongest first, inferred from their citations.
- Lewis C. Cantley
- William Pao
- H. Horlings
- Yardena Samuels
- B. Manning
- K. Inoki
- P. Jänne
- Dos D. Sarbassov
- Y. Yarden
- K. Okkenhaug
Who trusts J. Engelman overall
- Carlos L. Arteaga
- M. V. Vander Heiden
- T. Yuan
- R. Roskoski
- Ingrid A. Mayer
- F. Janku
- A. De Luca
- Lewis C. Cantley
- D. Fruman
- B. Chan
Papers from J. Engelman's perspective
Ordered by how strongly the researchers J. Engelman trusts endorse each paper. Same corpus, a different order for every researcher.
- High Frequency of Mutations of the PIK3CA Gene in Human Cancers (Science)
- EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy (Science)
- Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification (Science)
- EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. (New England Journal of Medicine)
- Akt regulates growth by directly phosphorylating Tsc2 (Nature Cell Biology)
- Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
- Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. (Proceedings of the National Academy of Sciences of the United States of America)
- TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling (Nature Cell Biology)
- KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib (PLoS Medicine)
- mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways (Nature Medicine)
Their papers
- Systematic identification of genomic markers of drug sensitivity in cancer cells (2012) — 2,417 citations
- Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers (2008) — 1,344 citations
- The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism (2006) — 3,342 citations
- EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib (2012) — 944 citations
- Targeting PI3K signalling in cancer: opportunities, challenges and limitations (2009) — 2,465 citations
- MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling (2007) — 4,374 citations
- Anchored multiplex PCR for targeted next-generation sequencing (2014) — 832 citations
- The PI3K pathway as drug target in human cancer. (2010) — 1,284 citations
- Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors (2011) — 3,396 citations
- PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. (2007) — 708 citations
- Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition (2016) — 897 citations
- Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers (2012) — 1,322 citations
- ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics (2014) — 952 citations
- Ceritinib in ALK-rearranged non-small-cell lung cancer. (2014) — 659 citations
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway (2017) — 1,715 citations
- Prospects for combining targeted and conventional cancer therapy with immunotherapy (2017) — 862 citations
- Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints (2016) — 1,425 citations
- Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK-Rearranged Lung Cancer (2016) — 1,054 citations
- EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer (NSCLC): A Retrospective Analysis (2016) — 1,124 citations
- Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin (2015) — 866 citations