Bryan L. Roth
Molecular Biology · 2000–2021
A researcher in the Science corpus: 32 papers; trusts 21 researchers and is trusted by 13 researchers here, as inferred from the citation graph.
Subfields
- Molecular Biology — 242 citations into it; #4,171 of 17,773 by trust here, #741 by citations
- Cellular and Molecular Neuroscience — 102 citations into it; #1,762 of 2,998 by trust here, #117 by citations
- Computational Theory and Mathematics — 73 citations into it; #8,957 of 12,182 by trust here, #192 by citations
- Computational Chemistry & Drug Discovery — 35 citations into it
- Cognitive Neuroscience — 24 citations into it
- Radiology, Nuclear Medicine and Imaging — 18 citations into it
- Endocrine and Autonomic Systems — 14 citations into it
- Biomedical Engineering — 5 citations into it
Whom Bryan L. Roth trusts overall
Their strongest outbound trust, strongest first, inferred from their citations.
- Deniz Atasoy
- Yexica Aponte
- M. Krashes
- Viviana Gradinaru
- X. Chen
- Scott Sternson
- S. Dewire
- Brian K. Shoichet
- Feng Zhang
- Joseph B. Kruskal
Who trusts Bryan L. Roth overall
- Michael Kuhn
- Yuhao Wang
- A. Hopkins
- Mehmet Gönen
- J. Lamb
- Yoshihiro Yamanishi
- Anna Gaulton
- Monica Campillos
- Jianyang Zeng
- Damian Szklarczyk
Papers from Bryan L. Roth's perspective
Ordered by how strongly the researchers Bryan L. Roth trusts endorse each paper. Same corpus, a different order for every researcher.
- Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
- Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. (Neuron)
- Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist (Proceedings of the National Academy of Sciences of the United States of America)
- DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. (Annual Review of Pharmacology and Toxicology)
- Structure of the human kappa opioid receptor in complex with JDTic (Nature)
- Activation of VTA GABA neurons disrupts reward consumption (Neuron)
- Millisecond-timescale, genetically targeted optical control of neural activity (Nature Neuroscience)
- A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping (Journal of Neuroscience)
- Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
- Basic local alignment search tool.
Their papers
- Relating protein pharmacology by ligand chemistry (2007) — 2,137 citations
- Ultra-large library docking for discovering new chemotypes (2019) — 846 citations
- Predicting new molecular targets for known drugs (2009) — 1,590 citations
- The Multiplicity of Serotonin Receptors: Uselessly Diverse Molecules or an Embarrassment of Riches? (2000) — 360 citations
- A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing (2020) — 3,895 citations
- Automated design of ligands to polypharmacological profiles (2012) — 781 citations
- Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia (2004) — 1,132 citations
- Ligand Discovery from a Dopamine D3 Receptor Homology Model and Crystal Structure (2011) — 299 citations
- Structure–based discovery of opioid analgesics with reduced side effects (2016) — 863 citations
- Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist (2002) — 711 citations
- 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology (2018) — 228 citations
- The Expanded Biology of Serotonin (2009) — 1,924 citations
- The promise and peril of chemical probes (2015) — 739 citations
- STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE (2018) — 437 citations
- Functional Selectivity and Classical Concepts of Quantitative Pharmacology (2007) — 1,147 citations
- Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology (2003) — 980 citations
- Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand (2007) — 1,970 citations
- Structural basis for Smoothened receptor modulation and chemoresistance to anti-cancer drugs (2014) — 258 citations
- Structural Features for Functional Selectivity at Serotonin Receptors (2013) — 685 citations
- PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome (2015) — 610 citations