Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.

By Eran Meshorer, D. Yellajoshula, E. George, P. Scambler, David T Brown, Tom Misteli. Developmental Cell, 2006

1,051 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ffb48fac342eb9849fc92d95344484bcf89a9529

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Distinct factors control histone variant H3.3 localization at specific genomic regions (2010, background): “Hira / , Atrx, and Atrx ESCs have been described previously (Garrick et al., 2006; Meshorer et al., 2006).”
The mammalian epigenome. (2007, background): “In yeast (which lack DNA methylation), interactions between hypoacetylated histones and SIR proteins ( S. cerevisiae ) or between H3K9 methylated histones and the Swi6 chromodomain ( S. pombe ) maintain the heterochromatic state through cell division (Grewal and Moazed, 2003).”
Global transcription in pluripotent embryonic stem cells. (2008, methodology): “In contrast, in R1 NPCs chromatin is heterogeneous in appearance and distinct heterochromatin domains are frequently present (Figure S1A, middle; Meshorer et al., 2006).”
A Myc rather than core pluripotency module accounts for the shared signatures of embryonic stem and cancer cells (2010, neutral): “between Embryonic Stem and Cancer”
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. (2007, background): “…dispersed, euchromatic nuclei, elevated amounts of histone modifications associated with open chromatin, such as acetylated histone H3 and H4, and reduced amounts of histone modifications associated with heterochromatin, such as histone H3 lysine9 trimethylation (H3K9me3) (Meshorer et al., 2006).”
A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “ES cell chromatin proteins have been reported to be in a hyperdynamic state (Meshorer et al., 2006).”
How is pluripotency determined and maintained? (2007, background): “chromatin (Weintraub and Groudine, 1976), are frequently detected in genes regardless of their expression levels in ES cells (Meshorer et al., 2006).”
A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation. (2012, background): “It has been previously proposed that the hyperdynamic binding of linker histone H1 is a functionally important hallmark of pluripotent stem cells, which allows generation of an active, ‘‘breathing’’ chromatin state (Meshorer et al. 2006).”
Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, background): “For example, in undifferentiated ESCs some structural chromatin proteins are less stably bound (Meshorer et al., 2006), intergenic transcription has been reported to be more widespread (Efroni et al.”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “The unexpected finding is that PcG occupancy can also coexist around the TSS with the active mark, H3K4me3, to form what has been termed a bivalent stat”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Accordingly, the interaction between chromatin and its structural proteins, such as histone H2B, histone H3 and heterochromatin protein 1 (HP1) is more dynamic in ES cells and therefore their chromatin is more plastic (Meshorer et al., 2006).”
Myc's broad reach. (2008, background): “This idea is supported by quantitative measurements of binding site occupancy by other transcription factors indicating dwell times of seconds to minutes for many factors (Phair et al. 2004; Meshorer et al. 2006).”
Strategies and new developments in the generation of patient-specific pluripotent stem cells. (2007, background): “Pluripotent stem cells have open and active chromatin structures (Meshorer et al., 2006).”
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy (2011, background): “The key role here for reprogramming factors is probably the induction of a developmentally more naive, open-chromatin state marked by high epigenetic instabilit”