A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.
By K. Kamieniarz, A. Izzo, M. Dundr, Philipp Tropberger, L. Ozretić, J. Kirfel, E. Scheer, P. Tropel, Jacek R. Wisniewski, L. Tora and 3 more. 2012
96 citations recorded by the source corpus.
The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dynamic during spermatogenesis and marks undifferentiated cells such as induced pluripotent stem (iPS) cells and testicular germ cell tumors. We propose a model for H1.4K34ac as a novel regulator of chromatin function with a dual role in transcriptional activation.
Subfields: Molecular Biology
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Citations in the corpus
- Gene-specific H1 eviction through a transcriptional activator-p300-NAP1-H1 pathway (2019, background): “In addition, there are intriguing reports of (i) positive transcription functions of linker histones following specific covalent modification (Kamieniarz et al., 2012) or interactions with other transcription (co)factors (Kim et al.”
- The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells. (2013, background): “Purified H1 subtypes might also lack their originalmodifications, which are known to have important consequences for gene regulation (Kamieniarz et al., 2012;Weiss et al., 2010; Hergeth et al., 2011).”