Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.

By Ian Chambers, Douglas Colby, M. Robertson, Jennifer Nichols, Sonia A Lee, S. Tweedie, Austin G Smith. Cell, 2003

3,411 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/528adc169ad7343695d05f1eda2d37339430e8ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Control of developmental regulators by Polycomb in human embryonic stem cells. (2006, background): “…therefore, that inappropriate regulation of developmental regulators that are common targets of OCT4, NANOG, and PRC2 contributes to the inability to establish ES cell lines in OCT4, NANOG, and EZH2 mutants (Nichols et al., 1998; O’Carroll et al., 2001; Chambers et al., 2003; Mitsui et al., 2003).”
Control of Embryonic Stem Cell State (2011, background): “…regulators based on their relatively unique expression pattern in ESCs and genetic experiments showing that they are essential for establishing or maintaining a robust pluripotent state (Chambers et al., 2003; Chambers and Smith, 2004; Mitsui et al., 2003; Nichols et al., 1998; Niwa et al., 2000).”
Properties of the amniotic membrane for potential use in tissue engineering. (2008, background): “In addition, they also show high expression of octamer binding protein 4 (Oct-4) and Nanog (Reubinoff et al., 2000; Chambers et al., 2003).”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.”
Pluripotency: Toward a gold standard for human ES and iPS cells (2009, background): “Other commonly used markers include telomerase and alkaline phosphatase activity, as well as three genes demonstrated to be required for pluripotency, OCT4, Sox2 and NANOG (Nichols et al., 1998; Chambers et al., 2003; Mitsui et al., 2003) (Supplemental Tables 1 and 2).”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “[86] [87] [88] [89] [90] Compared to levels in benign tissues, Nanog messenger RNA (mRNA) is elevated in malignant tumors.”
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. (2006, background): “Several transcription factors, including Oct3/4 (Nichols et al., 1998; Niwa et al., 2000), Sox2 (Avilion et al., 2003), and Nanog (Chambers et al., 2003; Mitsui et al., 2003), function in the maintenance of pluripotency in both early embryos and ES cells.”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “Nanog promotes ES cell self-renewal and alleviates the requirement for Leukemia Inhibitory Factor (LIF) (Chambers et al., 2003; Mitsui et al., 2003).”
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. (2005, neutral): “Interestingly, when we tested both the expression of ES-cell-specific genes, such as Nanog (Chambers et al., 2003; Mitsui et al., 2003) and Zfp42/Rex1 (Ben-Shushan et al.”
A core Klf circuitry regulates self-renewal of embryonic stem cells (2008, background): “Nanog was identified as a factor that is able to sustain pluripotency in mouse ES cells, even in the absence of leukaemia inhibitory factor (LIF”