Taking dendritic cells into medicine

By R. Steinman, Jacques Banchereau. Nature, 2007

2,220 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/fe3ad0d65d222453442be43693563a788aef8989

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In Immunology

Citations in the corpus

Signalling through C-type lectin receptors: shaping immune responses (2009, background): “The recent advances in our understanding of antigen routing by CLRs and the antigen presenting capacity of specific DC subsets have greatly contributed to the design of vaccines that deliver the antigen to the desired intracellular compartment for MHC class I or II presentation 1, 73, 74 .”
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. (2008, background): “T cells are under the control of dendritic cells (DCs), which stimulate immunologically naive T cells after the efficient formation and presentation of specific peptide-MHC complexes (Banchereau and Steinman, 1998; Steinman and Banchereau, 2007).”
MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells (2009, neutral): “Each dot represents one miRNA probe [(1) hsa miR-155, (2) ambi miR-7084, (3) hsa miR-340, (4) hsa miR-368, (5) mmu miR-350].”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “An important question regarding the immune privilege of the CNS is whether there exists a population of dendritic cells (DCs), the professional antigen-presenting cells (APCs) of the immune system (12).”
The polarization of immune cells in the tumour environment by TGFβ (2010, background): “DCs are APCs that have a crucial role in the initial activation and subsequent regulation of immune response”
Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents. (2015, background): “Cross-priming is a complex process that requires not only the uptake of tumor-associated antigens (TAAs) and their redirection to the MHC class I presentation pathway, but also the proper maturation of DCs, which generally occurs as they migrate to specific anatomical sites allowing for optimal anti”
Type I interferon is selectively required by dendritic cells for immune rejection of tumors (2011, positive): “Type I IFN also directly enhances the function of DCs, which are central to the initiation of adaptive immune responses (Steinman and Banchereau, 2007).”
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans (2008, background): “Recent advances have demonstrated a fundamental role for the innate immune system, particularly Toll-like receptors (TLRs) and antigen-presenting cells such as dendritic cells (DCs), in controlling adaptive immune responses 4,5 .”
Vitamin D and Immune Function (2013, background): “APC are responsible for the initiation of the adaptive immune response as they present antigens to T cells and B cells and are able to modulate them by either immunogenic or tolerogenic signals such as cytokines and expression of co-stimulatory molecules [60–62].”
Dendritic-cell-based therapeutic cancer vaccines. (2013, neutral): “DC maturation (Steinman and Banchereau, 2007).”