MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells

By M. Ceppi, Patrícia M Pereira, I. Dunand-Sauthier, E. Barras, W. Reith, Manuel A. S. Santos, P. Pierre. Proceedings of the National Academy of Sciences of the United States of America, 2009

761 citations recorded by the source corpus.

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin-1 (TLR/IL-1) inflammatory pathway as a general target of miR-155. We further demonstrate that miR-155 directly controls the level of TAB2, an important signal transduction molecule. Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/3045a05f2bd7c31fc84936230126ff62353312a1

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Citations in the corpus

MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011, background): “Inhibition of miR-155 in DCs resulted in upregulated expression of components of the p38 mitogen-activated protein kinase (MAPK) pathwa”
Akt1 controls macrophage response to LPS by regulating microRNAs (2009, background): “…TAK1-associated binding protein 2 (TAB2), a key molecule in the TLR4 signaling cascade, and thus inhibits TLR4 signals in dendritic cells (Ceppi et al., 2009) and that inhibition of miR-155 in BMDMs augments the expression of several proinflammatory mediators (Ruggiero et al., 2009),…”
microRNAs and the immune response (2009, background): “Studies into the mechanism of LPS-induced miR9, miR-146a and miR-155 expression demonstrate a central role of the pro-inflammatory transcription factor nuclear factor (NF)-kB [8 ,11,13].”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “In human myeloid-derived DCs, knockdown of miR-155 expression significantly increased protein expression of the pro-inflammatory cytokine interleukin-1β (IL-1β”
Pattern recognition receptors in health and diseases (2021, background): “Both of them will eventually reduce RA inflammation.(480) In addition, miR19a/b, miR-20a, and miR-10a are downregulated in RASF.”
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies (2014, background): “For example, TLR 3 is mainly expressed in mature myeloid DCs.”