The polarization of immune cells in the tumour environment by TGFβ

By R. Flavell, Shomyseh Sanjabi, Stephen H. Wrzesinski, P. Licona-Limón. Nature reviews. Immunology, 2010

943 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7d1a8ae5a95bdc0aa7f032022a7f37788caf2edc

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In Immunology

Citations in the corpus

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy (2019, background): “TGF-β can also restrict the secretion of interferon- γ (IFN-γ) by NK cells, which is crucial for stimulating effector CD4 TH1 cell-mediated antitumor reactions [68, 70].”
Programmed cell senescence during mammalian embryonic development. (2013, positive): “The recruitment of macrophages by senescent cells is a complex process incompletely understood (Hoenicke and Zender, 2012), where TGF-b plays a relevant role (Flavell et al., 2010).”
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer (2016, background): “Several lines of evidence suggest that HSCs reduce tumor immunosurveillance through paracrine signals to surrounding immune cells: (a) Cotransplantation studies demonstrated that HSCs inhibit lymphocyte infiltration in tumors and the spleens of tumor-bearing mice, induce apoptosis of infiltrating mo”
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “TGF-β has been widely reported to be a key cytokine connecting CAFs with NK cells in tumors [191].”
Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “TGF-β also inhibits the CD8+ T cells antitumor activity by suppressing the expression of several cytolytic genes, including the genes encoding granzyme A, granzyme B, IFN-γ, and FAS ligand [79, 84].”
Dependency of colorectal cancer on a TGF-beta-driven programme in stromal cells for metastasis initiation (2012, background): “Given the well-established role of TGF-b in the polarization and suppression of the immune system in tumors (Flavell et al., 2010), we tested whether the enhancement of tumor initiation by TGF-b signaling could be explained by modulation of the immune system.”