Vitamin D and Immune Function

By B. Prietl, Gerlies Treiber, T. Pieber, K. Amrein. Nutrients, 2013

1,037 citations recorded by the source corpus.

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.

Subfields: Nutrition and Dietetics, Pathology and Forensic Medicine, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/674cf354154648c94622d093bb6861d09227e48c

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Citations in the corpus

Immunologic Effects of Vitamin D on Human Health and Disease (2020, background): “Then, 1,25(OH)2D enhances antimicrobial activities of macrophages and monocytes in an autocrine fashion via VDR-RXR s gnaling, which, in turn, stimulates the productio of e dogen us antimicrobial cathelicidin LL-37 [1,2,5,17,18].”