Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

By Z. Tallóczy, Wenxia Jiang, Herbert W. Virgin, D. Leib, D. Scheuner, R. Kaufman, E. Eskelinen, Beth Levine. Proceedings of the National Academy of Sciences of the United States of America, 2001

793 citations recorded by the source corpus.

Subfields: Epidemiology, Plant Science, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/fd0088838461f8ac7c6f7840679b6fcfefed7b21

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Citations in the corpus

Autophagy regulates programmed cell death during the plant innate immune response. (2005, background): “5 (Talloczy et al., 2002). verexpression of mammalian beclin 1 protects mice rom fatal Sindbis virus infection (Liang et al., 1998). he mammalian autophagy gene, atg5, is required to egrade invasive group A Streptococcus (Nakagawa et l., 2004), and the induction of autophagy by starvation r…”
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. (2003, positive): “For analysis of autophagy by quantitative electron microscopy, Epon-embedded cells prepared as described previously (40) were used to determine the number of autophagic vacuole profiles per square micrometer of cell area.”
Autophagy and the integrated stress response (2010, positive): “Cells that carry a nonphosphorylatable mutant of eIF2a (S51A) fail to induce autophagy in response to starvation, suggesting that eIF2a phosphorylation on serine 51 (and by extension eIF2a kinases) plays a major role in autophagy regulation (Kouroku et al., 2007; Talloczy et al., 2002).”
PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “A diverse array of pathogens interact with components of the autophagic pathway including Brucellus abortus (80, 81), Coxiella burnetii (82), Porphyromonas gingivalis (83), Salmonella enterica (84), Chlamydia trachomatis (85), Listeria monocytogenes (86), Group A Streptococcus (87, 88), Mycobacteriu”
Autophagy in inflammation, infection, and immunometabolism (2021, background): “Autophagy has been shown to be induced by eIF2α kinase PKR (EIF2AK2), which recognizes dsRNA in the context of infection by a variety of DNA and RNA viruses, as a part of innate response (Talloczy et al., 2002).”
ER stress: Autophagy induction, inhibition and selection (2015, background): “Although it remains to be determined whether in vivo Eif2s1 deficiency is associated with autophagy regulation, conditional nonphosphorylated in vitro knockin (S51A) is associated with compromised autophagy.(41) Mice that lack Atf4 are neither embryonic lethal nor vulnerable to postnatal death.”
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium (2007, positive): “PKR and PKR-dependent phosphorylation of eIF2a is essential for autophagy in MEFs infected with herpes simplex virus, and eIF2a phosphorylation is required for starvation-induced autophagy in MEFs.(35) Thus, ER stress, starvation and viral infection appear signal autophagy by pathways that all depen”
Regulation and role of autophagy in mammalian cells. (2004, background): “…by the demonstration that two eIF2 kinases (GCN2 and PKR), which regulate stress-induced translation arrest by phosphorylating the translation factor eIF2 , positively controlled autophagic sequestration in yeast and mammalian cells in response to nutrient deprivation (Tallóczy et al., 2002).”
Autophagy: process and function. (2007, background): “One candidate sensor is GCN2, a tRNAbinding protein kinase (Tallóczy et al. 2002), and recent reports suggest the presence of other amino acid signaling pathways involving class III phosphatidylinositol 3 (PI3)-kinase and Beclin 1 (Byfield et al. 2005; Nobukuni et al. 2005).”
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation (2007, background): “lation has been shown during starvation-induced autophagy in Saccharomyces cerevisiae and during starvation- and virus-induced autophagy in mammalian cells.(31) In yeast,”
Autophagy and signaling: their role in cell survival and cell death (2005, background): “which regulate stress-induced translation arrest by phosphorylating the translation factor eIF2a, positively control autophagic sequestration in yeast and mammalian cells in response to nutrient deprivation.(37) There is a general consensus that amino acids do not directly affect the activity of pro”