Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.

By X. Qu, Jie Yu, G. Bhagat, Norihiko Furuya, H. Hibshoosh, Andrea B. Troxel, Jeffrey M. Rosen, E. Eskelinen, N. Mizushima, Y. Ohsumi and 2 more. Journal of Clinical Investigation, 2003

2,342 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b02adcacc02548a347fdf5f7be958680d7a52e65

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Citations in the corpus

Autophagy in the pathogenesis of disease. (2008, unknown): “Also, mice with a monoallelic deletion of beclin 1 display hyperproliferation of both mammary epithelial cells and splenic lymphocytes (Qu et al., 2003).”
Recent insights into the function of autophagy in cancer (2016, background): “…BECN1was lostwithhigh frequency inbreast, ovarian,and prostate cancer; that BECN1 overexpression suppressed human breast cancer cell line growth; and that mice with allelic lossofBecn1aretumor-prone (Aitaet al. 1999;Liang et al. 1999; Qu et al. 2003; Yue et al. 2003).”
Autophagy: a lysosomal degradation pathway with a central role in health and disease. (2009, background): “deletion of Beclin 1 have less autophagy andmore tumors than control mice [132,133].”
The molecular machinery of autophagy: unanswered questions (2005, background): “…ur na l o f C el l S ci en ce 8 various diseases in humans (reviewed by Shintani and Klionsky, 2004a), including cancer (Gozuacik and Kimchi, 2004; Qu et al., 2003; Yue et al., 2003), cardiomyopathy (Ueno et al., 2004) and neurodegenerative disorders such as Alzheimer’s, Parkinson’s and…”
The role of autophagy in cancer development and response to therapy (2005, unknown): “gov/cancertopics/types/lung">lung cancer , hepatocellular carcinoma, and lymphom”
Autophagy suppresses tumor progression by limiting chromosomal instability. (2007, background): “…in tumorigenesis, as haploinsuffieciency in the essential autophagy gene beclin1 is commonly observed in sporadic human ovarian, breast, and prostate cancers (Aita et al. 1999), and allelic loss of beclin1 promotes the incidence of sporadic malignancies in mice (Qu et al. 2003; Yue et al. 2003).”
Autophagy mediates the mitotic senescence transition. (2009, background): “On the other hand, the tumor-suppressive role of autophagy has been shown in mouse models, where Beclin-1 (Atg6 homolog) heterozygous and Atg4C-deficient mice are tumor prone (Qu et al. 2003; Yue et al. 2003; Karantza-Wadsworth et al. 2007; Marino et al. 2007).”