Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties.

By D. Ponti, Aurora Costa, N. Zaffaroni, G. Pratesi, G. Petrangolini, D. Coradini, S. Pilotti, M. Pierotti, M. Daidone. Cancer Research, 2005

1,873 citations recorded by the source corpus.

Subfields: Biotechnology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/fcf52107b8f1a4f22e4e6523e13ae905b7336734

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Citations in the corpus

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (2007, background): “In regard to the stem cell phenotype of MS, we show here that MS express a variety of genes that are upregulated in normal and cancer stem cell from various tissues, such as Bmi-1 (23, 40), CD44 (28, 29), Oct-4 (27), BCRP-I (33), and CD133 (31, 32).”
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (2011, methodology): “In vitro enrichment of CICs has been achieved by growth as cellular sphere”
Cancer stem cells: an old idea--a paradigm shift. (2006, background): “endothelial growth factor (VEGF) and were highly angiogenic (31).”
Spherical Cancer Models in Tumor Biology (2015, background): “…morphology and remain poorly differentiated, with little or no expression of differentiation markers that include cytokeratin (CK) 20 in colon cancers [110]; GFAP or β -tubulin 3 in brain tumors [36]; CK18, CK14, and α -SMA in breast cancers [38]; and CK7 and CA-125 in ovarian cancers [70].”
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. (2011, neutral): “were as in Ponti et al. (2005). Statistical analyses were done with Prism soft-”
Cancer stem cells: an evolving concept (2012, background): “Subsequently, similar conditions were reported to support the growth of human breast cance”
CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis (2006, background): “Several studies implicated a subset of human breast cancer cells as having enhanced ability to form tumors in immunocompromised mice [9,10].”
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state (2011, background): “The CSC phenotype of the different CD44 cell populations was assessed in vitro by assessing tumorsphere-forming ability, where only CSC-derived tumorspheres have the ability to be serially passaged (11, 24).”
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition (2008, background): “mammospheres, a property associated with mammary stem/ progenitor cells [3,26].”
Angiogenesis as a therapeutic target (2005, background): “Indeed, there is already a hint that the stem-cell subpopulation in breast cancer may be more adept at promoting angiogenesis than its non-stem-cell counterpar”
An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation (2009, neutral): “cancer cells is typical for other cancer cell lines ( Ponti et al., 2005; Chu et al., 2009).”
Cancer stem cells: models and concepts. (2007, background): “However, development of in vitro culture systems for the functional study of both normal (58) and cancer (59) human mammary epithelial cells could soon provide the experimental means for a phenotypic dissection of breast epithelial differentiation processes.”
Molecular definition of breast tumor heterogeneity. (2007, background): “Subsequent studies in breast and prostate cancer confirmed that CD44+ cells are tumorigenic when injected into immunodeficient mice and have progenitor-like properties (Patrawala et al., 2005; Ponti et al., 2005).”
Modelling breast cancer: one size does not fit all (2007, background): “The identification of cell-surface markers, CD44 + CD24 − and epithelial surface antigen (ESA) + , has allowed the isolation and characterization of these cell”