Cancer stem cells: an evolving concept

By Long V. Nguyen, R. Vanner, P. Dirks, C. Eaves. Nature Reviews. Cancer, 2012

1,186 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3d4dc67c7d095a11d90714be852419e9fa68d019

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. V. Plaks
2. Jing Yang
3. G. J. Yoshida
4. J. Dick
5. J. Tsai
6. S. Baylin
7. Niwen Kong
8. Zena Werb

In Oncology

1. Antonija Krešo
2. V. Plaks
3. Jing Yang
4. Zena Werb
5. G. J. Yoshida
6. J. Dick
7. J. Tsai
8. S. Baylin

Citations in the corpus

• Metabolic reprogramming: the emerging concept and associated therapeutic strategies (2015, background): “This cellular heterogeneity can be explained by a hierarchical model, in which cancer stem-like cells (CSCs) can provide transient amplifying cells and differentiated non-CSCs involved in establishing the tumor tissue [4, 5].”
• Evolution of the cancer stem cell model. (2014, background): “…nongenetic determinants, largely related to developmental pathways and epigenetic mod-ifications (DNA methylation, histone modification, chromatin openness, microRNA [miRNA], and other noncoding RNA) contribute to functional heterogeneity (Dick, 2008; Meacham and Morrison, 2013; Nguyen et al., 2012).”
• Cancer epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance (2014, background): “From a histologic and cell population standpoint phenotypic heterogeneity in tumor tissues has long been observed (Beck and Blanpain, 2013; Nguyen et al., 2012; Wang and Dick, 2008).”
• Epithelial–mesenchymal plasticity in carcinoma metastasis (2013, background): “The role of CSCs or TICs in tumor progression has been at the forefront of cancer research in recent years (Nguyen et al. 2012).”
• Mechanisms and insights into drug resistance in cancer (2013, background): “In the CSC model, rare populations of cancer stem cells possess tumor-initiating properties (Teicher, 2006; Nguyen et al., 2012).”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “Within this tumor heterogeneity, cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity, and clonal long-term repopulation potential (Clarke et al., 2006; Nguyen et al., 2012).”