Cancer stem cells: an old idea--a paradigm shift.

By M. Wicha, Suling Liu, G. Dontu. Cancer Research, 2006

1,452 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/9e6aa1986d48f16c0487dd62c1162f5c1f2e7e86

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Citations in the corpus

Signal transduction by focal adhesion kinase in cancer (2009, background): “A major conceptual advance in cancer research in recent years is the proposed role of cancer stem cells in the initiation and progression of various cancers [168, 169].”
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth (2011, neutral): “Stem cells or their immediate progeny can give rise to various tumor-contributing cells through a dysregulated self-renewal process (Wicha et al., 2006), but the origin of many niche cells critical for tumor growth (Li and Neaves, 2006) has not been established.”
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. (2006, background): “We have hypothesized that an early event in carcinogenesis may involve dysregulation of stem cell self-renewal leading to a clonal expansion of initiated stem cells (1, 2).”
Curcumin and cancer: an "old-age" disease with an "age-old" solution. (2008, background): “Even though substantial advances in therapy and diagnosis have enhanced the survival rate of patients with breast cancer, late recurrences of the disease account for more than 60% of deaths from breast cancer [5]; the survival rate among patients with metastatic disease does not seem to be significa”
Molecular definition of breast tumor heterogeneity. (2007, background): “Putative cancer stem cells have been purified from various human tumor types, frequently using cell surface markers specific for the normal stem cells of the same organ (Clarke and Fuller, 2006; Lynch et al., 2006; Polyak and Hahn, 2006; Weissman, 2005; Wicha et al., 2006).”
HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion (2008, background): “It has been suggested that tumor invasion and metastasis may be mediated by the cancer stem cell population (Sheridan et al., 2006; Wicha et al., 2006).”
Identification and characterization of ovarian cancer-initiating cells from primary human tumors. (2008, background): “Moreover, CD44CD117 cells from T1 and T2 graft tumors were serially transplantable in three consecutively injected mice (Table 2), with serial grafts having similar CD44CD117 percentages with mostly CD44 CD117 cells (Supplementary Table S3), thus demonstrating multipotent differentiation of the doub”