Angiogenesis as a therapeutic target

By N. Ferrara, R. Kerbel. Nature, 2005

2,677 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/19591ab68a155b2d341266c48a9ef957bd4ba612

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Adamis
2. J. Pouysségur
3. J. Chiche
4. M. Shibuya
5. S. Werner
6. Matthias Schäfer
7. B. Fredholm
8. Xiumin Wu

In Molecular Biology

1. A. Adamis
2. J. Pouysségur
3. J. Chiche
4. S. Apte
5. M. Shibuya
6. N. Ferrara
7. S. Werner
8. Matthias Schäfer

Citations in the corpus

• ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. (2010, background): “Following de novo formation of the vasculature from undifferentiated mesodermal precursors during embryogenesis (vasculogenesis), endothelial cells (ECs) proliferate and migrate to generate new capillaries from pre-existing blood vessels, a process termed angiogenesis.(1,2) Angiogenesis is critical ”
• Ten years of anti-vascular endothelial growth factor therapy (2016, background): “…, although subsequent studies revealed infrequent adverse events including gastrointestinal perforations, nephrotic syndrome and arterial thromboembolic complications such as myocardial infarction and stroke, especially in patients with a prior thromboembolic event or of age 65 or older 69,71,72 .”
• Combining Immunotherapy and Targeted Therapies in Cancer Treatment (2012, background): “Vascular endothelial growth factor A (VEGFA) is best known for its effects on angiogenesi”
• Adenosine, an endogenous distress signal, modulates tissue damage and repair (2007, background): “Indeed, blockade of angiogenesis provides additional benefit in tumor therapy.(42) The formation of functional blood vessels appears to require”
• Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies. (2011, background): “Molecular cloning, however, revealed that these 2 proteins were identical and encoded by a single gene.(3) The VEGF family includes VEGF-A, VEGFB, VEGF-C, VEGF-D, PlGF (placental growth factor), VEGF-E (Orf-VEGF), and Trimeresurus flavoviridis svVEGF.”