IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.

By P. Sansone, G. Storci, S. Tavolari, T. Guarnieri, C. Giovannini, M. Taffurelli, C. Ceccarelli, D. Santini, P. Paterini, K. Marcu and 2 more. Journal of Clinical Investigation, 2007

791 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/9167dd6a83c494502ab40025274fff72b278a672

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Citations in the corpus

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells (2009, background): “Primary human breast tumor cells (Sansone et al., 2007) and human breast cancer cell lines (Sasser et al.”
Targeting interleukin-6 in inflammatory autoimmune diseases and cancers. (2014, background): “Autocrine IL6 was shown to promote the growth of mammospheres and MCF-7derived spheroids and induces a hypoxia-resistant invasive phenotype (Sansone et al., 2007).”
Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “Autocrine production of IL-6 has also been shown to enhance the capacity to invade the extracellular matrix in breast cancer [143].”
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “It has been demonstrated that IL-6 drives the progression toward the acquisition of a malignant phenotype of cancer cells (15) and that the blockade of IL-6 signaling has strong effects in vivo on tumor progression, interfering broadly with tumor-supportive stromal functions, including angiogenesis,”
IL-6 in inflammation, autoimmunity and cancer (2020, background): “The IL-6–Notch-3 pathway is also involved in cell growth and the promotion of a hypoxia-resistant/invasive phenotype in breast cancer development (109).”
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks (2011, background): “IL6 has also been reported to be capable of regulating breast stem cells (22) and colon CSCs (23).”
IL-6 and STAT3 are required for survival of intestinal epithelial cells and development of colitis associated cancer (2009, background): “…associated with underlying chronic inﬂammation, IL-6 produced by epithelial and cancer cells may still contribute to tumorigenesis in models without an obvious inﬂammatory component (Ancrile et al., 2007; Gao et al., 2007; Grivennikov and Karin, 2008; Hodge et al., 2005; Sansone et al., 2007).”
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “Activated nuclear STAT3 has been detected in many forms of cancer, including breast, colon, gastric, lung, head and neck, skin, prostate and others (2,32,43,44).”
Recent advances in three‐dimensional multicellular spheroid culture for biomedical research (2008, background): “Examples of gene targets studied include caspase [29], interleukin-6 [30], E-cadherin [31], urokinase-type plasminogen activator (uPA), and its receptor [32].”