PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

By Margaret A. Lawlor, D. Alessi. Journal of Cell Science, 2001

1,181 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fcd201e834a38b477c99914e9dd2846f38140a17

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In Molecular Biology

1. David M. Sabatini
2. M. Laplante
3. K. Guan
4. T. Balla
5. K. Inoki
6. D. Alessi
7. M. Valko
8. B. Burgering

Citations in the corpus

• SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. (2006, background): “Among these are proteins implicated in metabolism, cell growth, and proliferation such as GSK3, mTOR, and TSC2, and proteins that play roles in apoptosis such as BAD, ASK1, and the Forkhead family of transcription factors FoxOs (Lawlor and Alessi, 2001).”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Akt/ PKB have several downstream targets that are part of the cell survival pathway (860, 1620, 1806).”
• Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling (2008, background): “Akt has an important function in cell growth, proliferation and inhibition of apoptosis (Lawlor and Alessi, 2001).”
• Apoptosis - the p53 network (2003, background): “PI3K activates AKT, a serine/threonine kinase, through phosphorylation on Ser473 by the 3′-phosphoinositide-dependent kinase PDK1 (Lawlor and Alessi, 2001).”
• Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D (2002, background): “In mammals the PI3K/PKB pathway is stimulated by a variety of growth factors, by cytokines, and by cell-matrix interactions, and it controls many biological functions including cell proliferation, survival, and insulin responses (27).”
• PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (2005, background): “Hyperactivation of Akt tips the balance of cells into prosurvival pathways and is often correlated with tumor progression, whereas reduced activity of Akt tips the balance toward apoptosis and is often correlated with heart disease and diabetes (Lawlor and Alessi, 2001; Matsui et al., 2003).”
• Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “Insuline-activated protein kinase B (PKB) propagates insulin signalling and promotes the phosphorylation of IRS1 on serine residue which in turn generates a positive-feedback loop for insulin action (Lawlor & Alessi, 2001).”
• PKD1/PKCμ promotes αvβ3 integrin recycling and delivery to nascent focal adhesions (2004, background): “of other pathways under control of the same upstream kinases (Lawlor and Alessi, 2001), we wished to confirm”
• Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics (2007, background): “and GSK3, which increases and decreases, respectively, their activities [123].”
• Regulation and role of autophagy in mammalian cells. (2004, neutral): “3) (Di Cristofano & Pandolfi, 2000; Lawlor & Alessi, 2001; Testa & Bellacosa, 2001; Vogt, 2001; Weaver & Ward, 2001; Young & Povey, 1998).”