Pungent products from garlic activate the sensory ion channel TRPA1.
By D. Bautista, P. Movahed, Andrew Hinman, Helena E Axelsson, O. Sterner, E. Högestätt, D. Julius, S. Jordt, P. Zygmunt. Proceedings of the National Academy of Sciences of the United States of America, 2005
849 citations recorded by the source corpus.
Subfields: Biochemistry, Food Science, Sensory Systems
View Paper: https://www.semanticscholar.org/paper/fcba28185c28567fb9e09bd7e3a4ebee0063c428
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Citations in the corpus
- TRPM8 is required for cold sensation in mice. (2007, neutral): “to jump. Similarly, cold plates have also been used to assay cold nociception ( Bautista et al., 2005; Kwan et al., 2006).”
- TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, neutral): “In cultured rat DRGs, two distinct populations of neurons have been reported to respond to cold: one group of cells is activated at innocuous cold temperatures and is menthol sensitive; these neurons presumably express TRPM8.”
- TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, positive): “Indeed, this is consistent with more recent studies examining the expression of TRPA1 in trigeminal or dorsal root ganglia using histological methods (Bautista et al., 2005; Kobayashi et al., 2005; Nagata et al., 2005).”
- Trp ion channels and temperature sensation. (2006, background): “(Bandell et al. 2004, Bautista et al. 2005, Jordt et al. 2004, Macpherson et al. 2005).”
- TRP Channels (2012, neutral): “In addition, TRPA1 functions as a quite promiscuous chemosensor, as it can be activated by a broad variety of natural compounds such as allyl isothiocyanate [the pungent compound in mustard oil (MO) and wasabi], allicin (from garlic), cinnemaldehyde (from cinnamon), menthol (from mint), tetra-hydroc”
- Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, neutral): “…by some other agents including methylsalicylate, icilin, and the environmental irritant, acrolein (Bandell et al., 2004; Jordt et al., 2004; Bautista et al., 2005, 2006) and mediates some responses to proinflammatory mediators, such as bradykinin (Bandell et al., 2004; Jordt et al., 2004;…”
- TRP channels and pain. (2013, background): “TRPM8 is robustly expressed by ∼15% of all somatosensory neurons encompassing mostly small-diameter, unmyelinated C-fibers, as well as a minor cohort of lightly myelinated Aδ fibers.”
- Mechanisms of sensory transduction in the skin (2007, background): “12 ), a member of the TRP ankyrin subfamily that is expressed in a subset of TRPV1-positive nociceptor”