Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin

By Erika L. Pearce, Alan C. Mullen, G. Martins, C. Krawczyk, Anne S. Hutchins, Valerie P. Zediak, Monica Banica, Catherine B. DiCioccio, Darrick A Gross, C. Mao and 7 more. Science, 2003

1,126 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/fc5797d97af62b05bfdd4509e881e021a1cae43d

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In Immunology

1. Rafi Ahmed
2. E. Wherry
3. N. Restifo
4. S. Rosenberg
5. S. Kaech
6. C. June
7. Joseph C. Sun
8. L. Gattinoni

In Oncology

1. N. Restifo
2. S. Rosenberg
3. C. June
4. E. Wherry
5. Rafi Ahmed
6. L. Gattinoni
7. S. Kaech
8. D. Palmer

Citations in the corpus

• Regulatory T cells exhibit distinct features in human breast cancer (2016, neutral): “Likewise, several genes encoding proteins implicated in T cell effector function were differentially expressed by Tconv cells isolated from breast tumors when compared to peripheral blood Tconv cells (Pearce et al., 2003).”
• The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation (2012, background): “Eomes and T-bet redundantly regulate differentiation of CD8+ effector T cells (Intlekofer et al., 2005, 2008; Pearce et al., 2003).”
• Differentiation of Effector CD4 T Cell Populations (2010, neutral): “The differential requirement for T-bet for IFN-γ production by CD4 and CD8 T cells may be explained by the heightened expression of another T-box family member, Eomesodermin (Eomes), in CD8 T cells (71).”
• Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells (2009, background): “We next assessed whether inhibition of T eff cell development is associated with the suppression of eomesodermin (encoded by Eomes ), a master regulator of CD8 + T cell effector functio”
• Single-cell chromatin state analysis with Signac (2021, background): “This indicated that EOMES and TBX21 likely regulate these sites 49 , rather than TBX2 and highlights the ability of combined gene expression and DNA accessibility data to improve identification of TFs involved in regulating different cell states.”
• A human memory T-cell subset with stem cell-like properties (2011, background): “Transcripts encoding key regulators of effector differentiation and senescence, such as eomesodermi”
• Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin (2005, background): “Despite its possible involvement in the development and function of the cytotoxic lineages, there seems to be a substantial T-bet-independent component of CD8 + T cell and NK cell effector function and homeostasi”
• Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. (2014, neutral): “Coexpression of T-bet and Eomes as seen in cNK cells has also been observed for CD8 T cells (Pearce et al., 2003).”
• Death by a thousand cuts: granzyme pathways of programmed cell death. (2008, background): “Another Tbox family member, Eomesodermin, was recently identified in activated CD8+ T cells in mice and shown to drive perforin, GzmB, and IFN-γ expression when ectopically expressed in mouse Th2 CD4+ cells (41).”
• Inflammatory Cytokines as a Third Signal for T Cell Activation (2010, neutral): “transcription factors, several of which are known to play important roles in CD8 T cell differentiation including T-bet [29,30], eomesodermin [31] and Blimp-1 [32-35].”