Regulatory T cells exhibit distinct features in human breast cancer

By G. Plitas, Catherine Konopacki, Kenmin Wu, Paula D. Bos, M. Morrow, E. Putintseva, Dmitriy M. Chudakov, Alexander Y. Rudensky. Immunity, 2016

617 citations recorded by the source corpus.

Summary Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control different types of inflammatory responses. Treg cells are also found in human cancers, and studies in animal models suggest that they contribute to cancer progression. However, properties of human intratumoral Treg cells and those present in corresponding normal tissue remain largely unknown. Here, we analyzed features of Treg cells in untreated human breast carcinomas, normal mammary gland, and peripheral blood. Tumor-resident Treg cells were potently suppressive and their gene expression pattern resembled that of normal breast tissue, but not of activated peripheral blood Treg cells. Nevertheless, a number of cytokine and chemokine receptor genes, most notably CCR8, were upregulated in tumor-resident Treg cells in comparison to normal tissue resident ones. Our studies suggest that targeting CCR8 for the depletion of tumor-resident Treg cells may represent a promising immunotherapeutic approach for the treatment of breast cancer.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/eff9cadab72faa7d8359daf794131c9c1b4c5f54

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Citations in the corpus

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets (2019, background): “In humans, immunosuppressive CCR8+ Tregs infiltrate breast tumors and CCR8 high expression is correlated with poor prognosis (Plitas et al., 2016).”
Regulatory T Cells and Human Disease. (2020, background): “TCR repertoire of these populations finds little overlap (144, 154).”
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses (2017, neutral): “Survival analysis based on gene expression levels is also widely used for evaluating the clinical importance of a given gene (11).”
Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing. (2017, positive): “(A) The Venn graph showing the overlap of tumor Treg genes identified in this study with those from previous studies by De Simone et al. (2016) (p = 2e-85), Plitas et al. (2016) (p = 6e-129), and Tirosh et al. (2016) (p = 2.1e-141), determined by hypergeometric test.”
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects (2020, background): “Targeting CCR8 to inhibit the migration of tumour-resident Tregs might represent a promising immunotherapeutic approach for the treatment of breast cancer [162].”