Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

By A. Intlekofer, N. Takemoto, E. Wherry, Sarah A. Longworth, John T. Northrup, V. Palanivel, Alan C. Mullen, C. Gasink, S. Kaech, Joseph D. Miller and 8 more. Nature Immunology, 2005

1,351 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/560e56742b13948c54dd04e4060cdc2c3731f532

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In Immunology

1. Rafi Ahmed
2. M. Bevan
3. E. Wherry
4. F. Sallusto
5. A. Lanzavecchia
6. S. Kaech
7. K. Araki
8. V. Badovinac

Citations in the corpus

• Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells (2010, methodology): “…Perforin Gene Transcription through STAT5 and Eomes, but not T-bet The T-box transcription factors T-bet and Eomes are both required for normal CTL differentiation (Intlekofer et al., 2008; 82 Immunity 32, 79–90, January 29, 2010 ª2010 Elsevier Inc. Intlekofer et al., 2005; Joshi et al., 2007).”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “and memory T cell potential are intertwined, but the precise mechanism is unclear (Intlekofer et al., 2005; Joshi et al., 2007; Takemoto et al., 2006; Wu et al., 2002).”
• Differentiation of Effector CD4 T Cell Populations (2010, positive): “T-bet and Eomes are also involved in regulating IL-2Rβ, whose expression is critical for IL-15-mediated CD8 T cell memory (74).”
• TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway (2016, background): “Note that the abundance of CD122, the IL-15Rb chain, was substantially decreased in abundance by both rapamycin and TGF-b at this late time point.”
• Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1 (2010, background): “The longevity of memory T cells, in contrast, depends on IL-15 (Schluns and Lefrançois, 2003), and the IL-15 responsiveness is supported by eomesodermin-mediated positive regulation of IL-2 receptor b chain (IL-2Rb) (Intlekofer et al., 2005).”
• The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage (2008, background): “…et al., 2005), Gata-3 (Kim et al., 2006), and T-bet (Matsuda et al., 2006) showed partial defects of NKT cells as well as T cells and NK cells (Egawa et al., 2007; Intlekofer et al., 2005; Lacorazza et al., 2002; Pai et al., 2003; Samson et al., 2003; Taniuchi et al., 2002; Townsend et al., 2004).”