AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora.

By Yi-hu Dong, Jin‐Ling Xu, Xianzhen Li, Lian-Hui Zhang. Proceedings of the National Academy of Sciences of the United States of America, 2000

769 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/fb37841396f9b05840e370bf432501e7b887fdbb

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Citations in the corpus

Disruption of bacterial quorum sensing: an unexplored strategy to fight infections in aquaculture (2004, background): “Indeed, several in vivo studies showed that the degradation of AHLs might continue until below the level needed for activation of quorum sensing-regulated virulence genes (Dong et al., 2000; Molina et al., 2003; Uroz et al., 2003; Dong et al., 2004).”
The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa (2012, background): “(56) and was subsequently found in the genomes of countless bacteria and eukaryotes (26, 54, 133, 145, 153, 170, 203, 213, 216).”
Rhizosphere engineering and management for sustainable agriculture (2009, background): “The aiiA gene from Bacillus sp. (Dong et al. 2000, 2002) was transferred to potato (Solanum tuberosum) to generate transgenic lines that indeed inactivated NAHL (Dong et al. 2001).”
Molecular communication in the rhizosphere (2009, background): “They are illustrated by the following examples: (i) plants, which are genetically modified to gain the capacity to inactivate AHL because they express the AHL-lactonase AiiA of Bacillus, were more resistant to Pectobacterium carotovorum infection than the parental, wild-type plants (Dong et al. 2001”
Exploiting Quorum Sensing To Confuse Bacterial Pathogens (2013, background): “cabbage, carrot, and celery plants (57).”
Bacillus as PGPR in Crop Ecosystem (2011, background): “…thuringiensis which could effectively attenuate the virulence of Gram-negative bacterium Erwinia carotovora in the root system of pepper plant by QQ. Recent studies on B. thuringiensis show that many subspecies of this organism produce AiiA homolog enzymes to degrade AHLs (Dong et al. 2004, 2000).”
Quorum sensing: cell-to-cell communication in bacteria. (2005, background): “Many Bacillus species secrete an enzyme, AiiA, that cleaves the lactone rings from the acyl moieties of AHLs and renders the AHLs inactive in signal transduction (Dong et al. 2000).”
Bacterial Quorum Sensing in Pathogenic Relationships (2000, background): “Bacillus that is capable of degrading AHLs was discovered (22).”
Quorum-sensing in Gram-negative bacteria. (2001, background): “subtilis and showed that it was capable of inactivating acyl HSLs [318].”
Biological Control of Soilborne Plant Pathogens with Rhizosphere Bacteria (2009, background): “The engineered leaves and tubers showed little pathogen damage, whereas nontransgenic control plants had severe soft rot symptoms (Dong et al. 2000), demonstrating that engineered plants could degrade AHL signals effectively to block bacterial communication required for pathogenicity.”
Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector (2005, background): “Several authors have suggested enzymatic degradation of AHLs as a strategy employed by several organisms, including several Bacillus species, in minimizing the detrimental effects caused by QS-regulated products (12, 14, 28).”
Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections. (2003, background): “(27) found a Bacillus species that produced an enzyme, termed AiiA, that catalyzed the hydrolysis of AHL molecules.”