Exploiting Quorum Sensing To Confuse Bacterial Pathogens

By Breah LaSarre, Michael J. Federle. Microbiology and Molecular Reviews, 2013

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Nano-Strategies to Fight Multidrug Resistant Bacteria—“A Battle of the Titans” (2018, background): “Taking this into account, it isn't surprising that the targeting and disruption of QS signaling systems and consequently, of the biofilm production, set the pillar for future next-generation antivirulence therapies to be developed (LaSarre and Federle, 2013; Venkatesan et al., 2015; Jakobsen et al.,”
Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “As part of RetS/GacS/GacA/RsmA regulatory pathway, the retS gene is important for phenotypic shifting from acute to chronic infections (Lapouge et al., 2008; Moscoso et al., 2011).”
Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics (2022, background): “).(171) RpoS indirectly plays a subtle role in activating lasR and rhlR expression and modulating ~40% QScontrolled gene expression during the stationary phase.”
Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. (2014, background): “For alkaloids like berberine which exert both direct antibacterial and antivirulence effects, the implication is that these will, like the QS-inhibiting macrolide antibiotics [151], exert greater in vivo efficacy than their MIC evaluations suggest.”