Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector

By T. B. Rasmussen, T. Bjarnsholt, M. E. Skindersoe, M. Hentzer, P. Kristoffersen, Manuela Köte, J. Nielsen, L. Eberl, M. Givskov. Journal of Bacteriology, 2005

622 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/24a4f9e69c6ac77a723285452a6499d9bc4ee420

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. T. Bjarnsholt
2. Robert E. W. Hancock
3. Bernd H. A. Rehm
4. C. Beloin
5. J. Ghigo
6. M. Givskov
7. D. Lebeaux

In Molecular Biology

1. T. Bjarnsholt
2. M. Givskov
3. Niels Høiby
4. Søren Molin
5. O. Ciofu
6. Robert E. W. Hancock
7. Bernd H. A. Rehm
8. G. Berg

Citations in the corpus

• Biofilms in the Food Industry: Health Aspects and Control Methods (2018, background): “…to interfere with bacterial QS based on the inhibition of cell-to-cell communication include competitive binding of inhibitors to the QS receptors (Rasmussen et al., 2005), enzymatic degradation of QS signals (Dong et al., 2001), post-transcriptional control of QS genes via sRNAs (Perez-Martinez…”
• A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms (2006, background): “…are vulnerable to SDS treatment, shear forces, kanamycin treatment, tobramycin treatment, H2O2 treatment and polymorphonuclear neutrophils phagocytosis (Davies et al., 1998; Hassett et al., 1999; Hentzer et al., 2002; 2003; Shih and Huang, 2002; Bjarnsholt et al., 2005; Rasmussen et al., 2005).”
• Application of Quorum Quenching to Inhibit Biofilm Formation (2009, neutral): “In support of this, Rasmussen et al .”
• Plant-driven selection of microbes (2009, background): “It has been indeed found in several plants, that QS-inhibitors are produced (Bauer and Mathesius 2004; Degrassi et al. 2007; Hentzer et al. 2002; Rasmussen et al. 2005; Teplitski et al. 2000).”
• Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation (2008, background): “tions (3, 22, 29, 41, 42); however, only limited success has”
• Inhibition of Quorum Sensing Mechanism and Aeromonas hydrophila Biofilm Formation by Vanillin (2009, positive): “The crude extracts of certain parts of plants such as Allium sativum (Rasmussen et al ., 2005), Vanilla planifolia (Choo et al ., 2006); Conocarpus erectus, Bucida buceras, and Tetrazygia bicolor (Adonizio et al ., 2006) inhibit bacterial QS. Medicago truncatula produces at least 15 to 20 compounds…”
• Antibiotic resistance of bacterial biofilms. (2010, background): “mutants and from use of naturally occurring and artificially syntetized QSI 293 compounds (85)(86).”
• Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “Through screening of chemical libraries, different QS inhibitors have been identified, such as garlic extract and 1-isothiocyanato-3-(methylsulfinyl)propane, also known as iberin, from horseradish (311, 312).”
• The role of bacterial biofilms in chronic infections (2013, neutral): “and plant (141), nematode (142), and animal”
• Quorum sensing inhibitory and antimicrobial activities of honeys and the relationship with individual phenolics (2009, background): “been published regarding the QS activity of honey (Rasmussen et al., 2005).”