CNS synaptogenesis promoted by glia-derived cholesterol.

By D. Mauch, K. Naegler, S. Schumacher, C. Göritz, E. Müller, A. Otto, F. Pfrieger. Science, 2001

1,690 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/facc9e9b7cc3c95c004b03375880d30b8ea08fc6

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Citations in the corpus

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. (2012, positive): “In vitro studies have shown that cholesterol released from apoE-containing lipoprotein particles is used to support synaptogenesis (Mauch et al. 2001) and the maintenance of synaptic connections (Pfrieger 2003).”
Thematic review series: Brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal Published, JLR Papers in Press, May 16, 2004. DOI 10.1194/jlr.R400004-JLR200 (2004, background): “The stimulatory factor produced by these glial cells was found to be cholesterol coupled to apoE (171, 172).”
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types (2018, positive): “Cholesterol and other lipids are crucial for a wide range of cellular functions in the brain, and altered metabolism or transport appears to be associated with multiple pathological phenotypes in various neurodegenerative disorders (Go¨ritz et al., 2002; Mauch et al., 2001).”
Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, background): “In postnatal life, however, this ability is strongly reduced, and neurons have to rely on the delivery of cholesterol from astrocytes (376, 446).”
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. (2005, methodology): “, 2004), as well as with soluble astrocyte-derived signals such as cholesterol (Mauch et al., 2001) and an as yet unidentified signal reported here, that further help to promote preand postsynaptic function.”
Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “In vitro experiments coculturing astrocytes and neurons suggest that cholesterol is synthesized in astrocytes, packaged into ApoE particles, and secreted to be taken up by neurons and incorporated into membranes to augment synaptogenesis and vesicle formation (98).”
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. (2004, background): “[145] Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A, et al.”
Astroglia induce neurogenesis from adult neural stem cells (2002, background): “For example, astrocytes have been reported to induce and/or stabilize CNS synapse”
Lipid Rafts in the Maintenance of Synapses, Dendritic Spines, and Surface AMPA Receptor Stability (2003, background): “A recent report (Mauch et al., 2001) identified cholesterol as the glia-derived factor that promotes synapse formation between purified retinal ganglion neurons; however, why cholesterol is needed by neurons to develop mature synapses was not addressed.”
Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons (2002, background): “One of these glia-derived factors was recently identified as cholesterol in a complex with lipoproteins containing apolipoprotein-E (ref”