Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease.

By George Bartzokis. Neurobiology of Aging, 2004

968 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/02a47de5fd99269492f70421ab37499c32a770b3

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Citations in the corpus

Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation (2005, background): “…diseases including multiple sclerosis (Rodriguez et al., 1993), Pelizaeus-Merzbacher (Gow and Lazzarini, 1996), Alzheimer ‘s disease (Bartzokis, 2004), progressive multifocal leukoencephalopathy (Major et al., 1992), multisystem degeneration (Burn and Jaros, 2001), and…”
Differential aging of the brain: patterns, cognitive correlates and modifiers. (2006, positive): “Recently , a theory emphasizing the role of myelin rather than neurons in aging and age - related diseases was proposed ( Bartzokis , 2004a , b ) .”
Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging (2005, background): “A predilection of loss occurs for thin fibers, which are in greatest abundance in the frontal lobes and develop and mature later than large-diameter axons (Bartzokis, 2004).”
Life-span changes of the human brain white matter: diffusion tensor imaging (DTI) and volumetry. (2010, background): “It has been suggested that thin myelinated fibers more proximal to the brain surface or in the periphery of the fasciculi may be more vulnerable to age-related degradation than deeper structures (Sandell and Peters 2001, 2003; Marner et al. 2003; Bartzokis 2004).”
Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer's disease supports retrogenesis (2008, background): “…the abnormalities in WM we observed in patients with AD appear to be related to alterations of the integrity of myelin (Song et al., 2005), which is more in accordance with retrogenesis through mechanisms outlined by Bartzokis (2004) than with wallerian degeneration secondary to distal GM atrophy.”
Assessing the effects of age on long white matter tracts using diffusion tensor tractography (2009, background): “Thus, the current finding lends considerable support to the idea that age-related changes in white matter are largely driven by changes in myelination rather than by gross morphological changes in the axons themselves (Bartzokis, 2004).”
Age-related differences in white matter microstructure: Region-specific patterns of diffusivity (2010, background): “This should make the myelin sheaths more exposed to the potentially toxic extracellular environment and hencemore vulnerable (Bartzokis, 2004; Bartzokis et al., 2004).”
A Network Diffusion Model of Disease Progression in Dementia (2012, critical): “The network diffusion model does not support the ‘‘retrogenesis’’ hypothesis that AD is a WM-speciﬁc disease and is caused by demyelination of late myelinating ﬁber pathways (Bartzokis, 2004).”
Stages in the development of Parkinson’s disease-related pathology (2004, background): “Mesocortical and neocortical areas that undergo late myelination develop lesions earlier in the disease process and at higher densities than those that begin to myelinate early (Bartzokis 2004; Braak and Del Tredici 2004).”
Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. (2005, background): “Nonlinear shrinkage is consistent with age-related augmentation of age differences in other indices of white matter integrity, e.g. MRI relaxation times (Bartzokis et al., 2003, Bartzokis 2004) or the ratio of small to large myelinated axons (Tang et al., 1997).”
Iron, brain ageing and neurodegenerative disorders (2004, background): “Recent evidence indicates that ageing and AD are associated with a decline in myelin, and this could be related to the iron content of the myeli”