Molecular mechanisms and potential therapeutical targets in Huntington's disease.

By C. Zuccato, M. Valenza, E. Cattaneo. Physiological Reviews, 2010

850 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ef948ffd03d642b0d5bd85e4221db668c41d85c2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. L. Zuo
2. Zewen Liu
3. Undurti N. Das
4. Andrea Ballabio
5. Tingyang Zhou
6. Siresha Bathina

In Molecular Biology

1. Undurti N. Das
2. Andrea Ballabio
3. Toren Finkel
4. Navdeep S. Chandel
5. N. Tonks

Citations in the corpus

• Brain-derived neurotrophic factor and its clinical implications (2015, background): “Decrease in the expression of BDNF is seen in many neurological diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and bipolar disease [124–133], as detailed above.”
• Neurogenesis in the striatum of the adult human brain. (2014, neutral): “In Huntington’s disease, a neurodegenerative disease affecting striatal neurons (Walker, 2007; Zuccato et al., 2010), we find that postnatally generated neurons are absent in advanced stages of the disease.”
• Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. (2011, background): “In addition to LSDs, there is increasing evidence that lysosomes play a role in the pathogenesis of common neurodegenerative diseases such as Alzheimer’s (13), Parkinson’s (14) and Huntington’s (15), due to their involvement in autophagic clearance pathways.”
• Measuring in vivo mitophagy (2015, background): “Evidence suggests that in Huntington’s disease, mutant Huntingtin protein has a direct, deleterious effect on mitochondrial function, perhaps by impairing mitochondrial calcium homeostasis (Panov et al., 2002; Zuccato et al., 2010).”
• Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications (2017, background): “Although the involvement of mitochondrial alterations and ROS overproduction in HD progression is well evident, it is not clear which event occurs initially [66, 79, 80].”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, neutral): “Now it has been revealed that mutant Htt when inside the inclusion bodies, and as aggregated forms are less toxic than the soluble form of the protein (Zuccato et al., 2010).”