Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons

By Hong-jun Song, Charles F. Stevens, Fred H. Gage. Nature Neuroscience, 2002

685 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/b8cfc55ffb16eec788228f5c5a66f66cccafb88a

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In Developmental Neuroscience

Citations in the corpus

Functional significance of adult neurogenesis. (2004, background): “[8] found that co-culturing adult-derived precursor cells with astrocytes induced their development into electrically active neurons that formed networks in vitro.”
Short‐term and long‐term survival of new neurons in the rat dentate gyrus (2003, background): “A recent study has shown that 1-month-old granule neurons have also acquired several of the electrophysiological properties of mature granule cells (Song et al., 2002).”
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Not surprisingly, the importance of tissue conditions for precursor cell function, for example, factors contributed by astroglia, has become more apparent (Song et al. 2002a).”
Adult neurogenesis: from precursors to network and physiology. (2005, methodology): “Indeed, using virus-based transynaptic activity neuronal tracing (PVR GS518), the neurons generated in the DG have been shown to be synaptically integrated into the preexisting circuitry 4–8 wk after their birth (80), whereas they reach a mature morphology (soma size, total dendritic length, dendrit”
Adult neurogenesis and neural stem cells of the central nervous system in mammals (2002, background): “They receive synaptic input (Kaplan and Bell, 1983; Markakis and Gage, 1999) and project functional connections in vitro (Song et al., 2002) and in vivo to the CA3 region (van Praag et al., 2002).”
A hypothesis about the role of adult neurogenesis in hippocampal function. (2004, background): “When cultured in the presence of astrocytes, hippocampal NPCs produced neurons that generated action potentials, received functional GABAergic and glutamatergic synaptic inputs (45, 46), and could synthesize and release neurotransmitters (45).”
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Neuronal maturation and formation of functional synapses is dependent upon coculture with astrocytes from neonatal hippocampus (Song et al., 2002).”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, neutral): “For co-IP analysis, total proteins from hippocampi of adult C57BL/6 mice or from primary neuronal culture of P0 mouse hippocampus (Song et al., 2002) were prepared in the RIPA buffer containing 10% glycerol, 1% nonylphenoxypolyethoxy ethanol (Nonidet P-40), 50 mM Tris-Cl (pH 7.5), 200 mM NaCl, 2 mM…”
Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “In addition, adult neurogenesis occurs in microenvironments that consist of multiple, regionally specialized cell types, some of which may be glia (51, 53, 54, 156).”
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development (2005, background): “Finally, neurons derived from adult hippocampal NPCs make functional synapses in vitro (Toda et al., 2000; Song et al., 2002) and in vivo (van Praag et al.”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “These latter cells also progressively acquire electrophysiological characteristics of new mature granule neurons (73, 218).”
Integration of New Neurons into Functional Neural Networks (2006, background): “It has also been shown that, given adequate time for these newborn granule neurons to mature, they develop synaptic responsiveness and other electrophysiological properties similar to those of existing granule cells (Song et al., 2002; van Praag et al., 2002).”