Astroglia induce neurogenesis from adult neural stem cells

By Hongjun Song, Charles F. Stevens, Fred H. Gage. 2002

1,521 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “In addition, astrocytes derived from neurogenic hippocampus and SVZ, but not from nonneurogenic spinal cord, promote proliferation and neuronal fate commitment of multipotent adult neural stem cells in culture (Lim and Alvarez-Buylla, 1999; Song et al., 2002).”
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, background): “…contrast to new neurons, the number of hippocampal astrocytes increases with age (Mouton et al., 2002; Pilegaard and Ladefoged, 1996); furthermore, they have an instructive role in adult neurogenesis through promotion of neuronal differentiation and integration of young neurons (Song et al., 2002).”
The Adult Substantia Nigra Contains Progenitor Cells with Neurogenic Potential (2002, methodology): “For immediate differentiation experiments, two additional differentiation paradigms were applied: 1% FBS and 5 m of forskolin (Palmer et al., 1997) or astrocyte feeder layer in serum-free defined medium (Song et al., 2002).”
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis (2011, background): “Wnt3 is produced by local hippocampal astrocytes, regulating the generation of newborn granule cells (7, 8).”
Neurogenesis in the Adult Hippocampus. (2015, background): “Hippocampus-derived astrocytes, but not astrocytes from the spinal cord, have been demonstrated to regulate neuronal differentiation from neural stem cells or progenitor cells in vitro (Song et al. 2002).”
Delayed Development of Adult-Generated Granule Cells in Dentate Gyrus (2006, background): “Recent work with hippocampal progenitors demonstrates that the environment in vitro determines the phenotype of newborn cells (Song et al., 2002; Deisseroth et al., 2004; Shen et al., 2004).”
Mechanisms and functional implications of adult neurogenesis. (2008, positive): “They promote the neuronal differentiation of adult hippocampal progenitor cells and the integration of newborn neurons derived from adult hippocampal progenitors in vitro (Song et al., 2002).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “2005), support adult neurogenesis (Pixley 1992; Lim & Alvarez-Buylla 1999; Song et al. 2002; Kornyei et al. 2005) and act as neural stem cells in the adult brain (Doetsch et al.”
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “Several studies have indicated that stem cells themselves create a neurogenic microenvironment that provides signals for proliferation and differentiation (Lim and Alvarez-Buylla, 1999; Lim et al., 2000; Song et al., 2002; Lie et al., 2005; Favaro et al., 2009).”
A Novel Secretory Factor, Neurogenesin-1, Provides Neurogenic Environmental Cues for Neural Stem Cells in the Adult Hippocampus (2003, neutral): “A recent study proposed that astro - cytes were implicated in adult neurogenesis ; however , the sub - stance directing neurogenesis still remains to be elucidated ( Song et al .”
Neurogenesis in the adult brain: new strategies for central nervous system diseases. (2004, background): “In addition, adult neurogenesis occurs in microenvironments that consist of multiple, regionally specialized cell types, some of which may be glia (51, 53, 54, 156).”
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain (2004, background): “These deletion experiments cannot rule out the possibility that dividing GFAP-expressing cells may merely provide induction signals or support that are essential but not sufficient for neurogenesi”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, methodology): “Neural differentiation of the established NSCs with different apoE genotypes was induced in vitro as reported (Song et al., 2002).”
The glial identity of neural stem cells (2003, background): “The differential ability of astrocytes from distinct brain regions to support neurogenesi”