Evidence for Addiction-like Behavior in the Rat

By V. Deroche-Gamonet, D. Belin, P. Piazza. Science, 2004

1,097 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/f9f46ff8ccdaacfdbbd69068f1c357fa8fa2d26c

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Citations in the corpus

Reward Processing by the Opioid System in the Brain (2009, positive): “Finally, multidimensional models take into account several hallmarks of addiction to predict the development of addictive-like behavior in rats (33, 34, 100).”
The role of impulsive behavior in drug abuse (2008, background): “For example, rats that showed high levels of responding during cocaineprimed reinstatement of cocaine-seeking behavior showed greater deficits in inhibitory control on the go/no-go task compared with rats that had lower levels of reinstatement responding (Deroche-Gamonet et al. 2004).”
Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. (2008, neutral): “Such compulsive behavior, defined as persisting despite negative consequences (see also the Diagnostic and Statistical Manual IV; American Psychiatric Association, 1994) emerges only after long self-administration sessions and an extended, but not a brief, drug-taking history ( Deroche-Gamonet et al”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “Because we know the proximate cause of addiction, the drugs themselves, it has been possible to model some aspects of addiction in animals (Deroche-Gamonet et al. 2004, Vanderschuren & Everitt 2004) more effectively than it has been possible to model most psychiatric disorders.”
Addiction and the brain antireward system. (2008, background): “…drug seeking in the presence of an aversive conditioned stimulus or punishment, which has face validity for the DSM-IV criteria of “continued substance use despite knowledge of having a persistent physical or psychological problem” (Deroche-Gamonet et al. 2004, Vanderschuren & Everitt 2004).”
The incentive sensitization theory of addiction: some current issues (2008, background): “In one study, it took several months of intravenous (IV) cocaine self-administration before some rats began to develop addiction-like symptoms (Deroche-Gamonet et al. 2004), including continued drug seeking in the face of punishment or when drugs were known to be unavailable, increased motivation to”
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction (2008, background): “In the study by Deroche-Gamonet et al. (2004), three addiction-like behavioural criteria were measured in rats, namely (i) increased motivation to take the drug, (ii) inability to refrain from drug seeking, and (iii) maintained drug use despite aversive consequences.”
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. (2008, background): “The power of ‘‘craving’’ is evidenced by results showing that animals will sometimes face adverse consequences to obtain a substance of abuse such as cocaine or alcohol (Deroche-Gamonet et al., 2004; Dickinson et al., 2002; Vanderschuren and Everitt, 2004).”
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion (2005, background): “Compulsive drug seeking and drug taking are the hallmarks of the definitions of drug addiction (or 'dependence' in the Diagnostic and Statistical Manual IV ), which is becoming increasingly acknowledged by neuroscientists modeling this behavio”
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview (2006, background): “Thus, for example, Deroche-Gamonet et al. (2004) assessed the resistance to punishment during cocaine self-administration by simultaneously delivering both the drug and an electrical shock.”
Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “Periods of extended access to cocaine and other drugs of abuse can drive the emergence of compulsive drug-taking behaviors in rats (Ahmed and Koob, 1998; Deroche-Gamonet et al., 2004; Vanderschuren and Everitt, 2004).”
Addiction: a disease of learning and memory. (2005, background): “forts to develop animal models of addiction (98, 99) may”