Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction

By Barry J. Everitt, D. Belin, D. Economidou, Yann Pelloux, J. Dalley, Trevor W. Robbins. Philosophical Transactions of the Royal Society B: Biological Sciences, 2008

953 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Clinical Psychology, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/164d47d7f2e73773798471e399d1dbf6f7fed59e

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Citations in the corpus

Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “…and decision making (i.e., prefrontal cortex) and in interoceptive processing (insular cortex) have been heavily implicated in drug addiction (Everitt et al., 2008; Fineberg et al., 2010; Koob and Volkow, 2010; Naqvi and Bechara, 2009), yet little is known of their precise role in compulsive…”
The Brain on Drugs: From Reward to Addiction. (2015, background): “Specifically, studies in rodents and non-human primates have found reduced levels of D2R in the striatum, including in the NAc, upon chronic drug exposures, as well as in animals with a propensity to self-administer drugs (Everitt et al., 2008).”
The glutamate homeostasis hypothesis of addiction (2009, background): “A corticostriatal circuitry of addiction A common perspective on addiction is that, with repeated drug use, drug-seeking behaviours become more habitual and less amenable to regulation by environmental contingencies, a viewpoint developed in recent review”
Neurocircuitry of Addiction (2009, background): “These results suggest that the dorsal striatum may have a minor role in the acute reinforcing effects of psychostimulant drugs but a key role in the transition to compulsive use (Everitt et al, 2008).”
Neural substrates of smoking cue reactivity: A meta-analysis of fMRI studies (2011, positive): “Specifically, the dorsal striatum, which is involved in habit learning (Jog et al., 1999), is thought to control the " automatic " aspects of drug-taking behavior (Everitt et al., 2008) such as smoking a cigarette in the presence of cues without consciously attending to the cues.”
Cortico-Basal Ganglia Reward Network: Microcircuitry (2009, positive): “Deficits in reward-related activity are central to the anhedonia of depression (Hyman et al, 2006), and altered stimulus valuation is also a known component of attention-deficit hyperactivity disorder and obsessive-compulsive disorder (Cardinal et al, 2004; Everitt et al, 2008; Huey et al, 2008).”
Cognitive Bias Modification and Cognitive Control Training in Addiction and Related Psychopathology (2013, background): “…the result that after prolonged drug use, the addictive behavior can persist despite (lack of) reward or even punishment and can thus develop from an impulsive outcome-focused behavior to compulsive habitual behavior (Everitt et al., 2008; Everitt & Robbins, 2005; Vanderschuren & Everitt, 2004).”
‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, background): “discussed here, though I and others have recently discussed it elsewhere [33,104,113,114,116,119,120].”
Goals and Habits in the Brain (2013, background): “One influential proposal is that a protracted exposure to addictive drugs recruits dopamine-dependent striato-nigro-striatal ascending spirals (Haber et al., 2000; Joel and Weiner, 2000) from the nucleus accumbens to more dorsal regions of the striatum (Everitt et al., 2008).”
Problematic Use of Social Networking Sites: Antecedents and Consequence from a Dual-System Theory Perspective (2016, background): “, [29, 32]) has shown that different problematic behaviors share similar etiology in terms of a deficit in the balance (i.”
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli (2011, positive): “…and functionally related circuits that are involved in a wide range of adaptive and pathologically motivated behaviors (Wise, 2004; Everitt and Robbins, 2005; Ikemoto, 2007; Everitt et al., 2008; Berridge et al., 2009; Schultz, 2010; Bromberg-Martin et al., 2010; Ungless et al., 2010; Wolf, 2010).”
Implicit Cognition and Addiction: A Tool for Explaining Paradoxical Behavior (2010, background): “An important moderating role is further given to impulsivity, both in the onset of addictive behaviors and in the escalation to compulsive drug use (Everitt et al. 2008).”