Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum.

By D. Belin, Barry J. Everitt. Neuron, 2008

681 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/37e04594604adc73db24fea8d8a209f57b3e1411

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In Cellular and Molecular Neuroscience

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Citations in the corpus

The glutamate homeostasis hypothesis of addiction (2009, background): “The argument relies on the topography of both corticostriatal glutamatergic and mesencephalic-striatal dopaminergic projections that mediate the processing of sensory information into adaptive behaviour”
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling (2011, background): “One study implicated the recruitment of these dorsal parts of the DA system in cocaine-seeking habits by demonstrating that the surgical disconnection of the spiral via a lesion of the NAc core blocked the development of cocaine seeking in rats (Belin and Everitt, 2008).”
Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill (2009, result): “These findings provide a possible mechanism to explain previous results showing that these different striatal regions are involved in controlling goal-directed actions and automatic habitual responses, respectively, and that, with extended training, the control over behavior by the goal-directed sys”
The Reward Circuit: Linking Primate Anatomy and Human Imaging (2010, background): “The idea that this recruitment is likely to involve the dopamine pathways through the striato-nigro-striatal spiral is supported by animal behavioral studies (Belin and Everitt, 2008; Porrino et al, 2004).”
Sex Differences in Animal Models: Focus on Addiction (2016, background): “Male rats with lower nucleus accumbens dopamine were shown to be more impulsive and more likely to develop addiction-like behaviors (Belin and Everitt, 2008).”
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction (2008, background): “…and again underwent the disconnection manipulation, or bilateral dorsal striatal dopamine receptor antagonist infusions (in non-lesioned rats), immediately after acquisition when the behaviour was under response– outcome control; neither manipulation had any effect (Belin & Everitt 2008).”
Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “Chronic administration of drugs of abuse may lead to alterations in this serial connectivity and, as a result, drug-seeking habits (a key characteristic of addictive behavior) are triggered (30).”
Neurocircuitry of Addiction (2009, background): “Disconnection of the ventral striatum from the dorsal striatum in rats self-administering cocaine on a secondorder schedule only showed a deficit in animals with wellestablished ‘compulsive’ intake but not in animals that recently acquired the second-order schedule (Belin and Everitt, 2008).”