Reward Mechanisms in Obesity: New Insights and Future Directions
By P. Kenny. Neuron, 2011
737 citations recorded by the source corpus.
Food is consumed in order to maintain energy balance at homeostatic levels. In addition, palatable food is also consumed for its hedonic properties independent of energy status. Such reward-related consumption can result in caloric intake exceeding requirements and is considered a major culprit in the rapidly increasing rates of obesity in developed countries. Compared with homeostatic mechanisms of feeding, much less is known about how hedonic systems in brain influence food intake. Intriguingly, excessive consumption of palatable food can trigger neuroadaptive responses in brain reward circuitries similar to drugs of abuse. Furthermore, similar genetic vulnerabilities in brain reward systems can increase predisposition to drug addiction and obesity. Here, recent advances in our understanding of the brain circuitries that regulate hedonic aspects of feeding behavior will be reviewed. Also, emerging evidence suggesting that obesity and drug addiction may share common hedonic mechanisms will also be considered.
Subfields: Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/e25a583d69419c1dc57d5535b357f7902cd9003f
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Endocrine and Autonomic Systems
In Nutrition and Dietetics
Citations in the corpus
- Dopaminergic neurons encode a distributed, asymmetric representation of temperature in Drosophila (2013, background): “…variety of behaviors in animals, including learning (Wise, 2004; Davis, 2011), arousal (Andretic et al., 2005), motor control (Hauber, 1998), motivation (Wise, 2004), addiction and obesity (Kenny, 2011; Lüscher and Malenka, 2011), and salience-based decisionmaking (Zhang et al., 2007; Doya, 2008).”