Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

By Barry J. Everitt, Trevor W. Robbins. Nature Neuroscience, 2005

3,720 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/70ab5992627e457241c0648ebffc7ed2edc84303

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Citations in the corpus

The mysterious motivational functions of mesolimbic dopamine. (2012, neutral): “…during instrumental behavior (Salamone et al., 1994, 2007, 2012; Mai et al., 2012), Pavlovian to instrumental transfer (Parkinson et al., 2002; Everitt and Robbins, 2005; Lex and Hauber, 2008), flexible approach behavior (Nicola, 2010), energy expenditure and regulation (Salamone , 1987;…”
Generalization of value in reinforcement learning by humans (2012, background): “However, basic reinforcement learning is relatively limited in scope and does not explain how learning about stimulus regularities or relations may guide decision-making.”
‘Liking’ and ‘wanting’ food rewards: Brain substrates and roles in eating disorders (2009, background): “Addicts sometimes take drugs compulsively even when they do not derive much pleasure from them [8,128].”
Dopamine signals for reward value and risk: basic and recent data (2010, background): “These results confirm the notion of a global positive reinforcing function of dopamine systems derived from earlier lesioning, electrical self-stimulation and drug addiction work [1,2].”
Computational psychiatry as a bridge from neuroscience to clinical applications (2016, background): “This would account for the prominent goal-seeking features of drug addiction 125 .”
What is reinforced by phasic dopamine signals? (2008, background): “…debilitating conditions including Parkinson's disease, Huntington's disease, Tourette's syndrome, schizophrenia, attention-deficit disorder, obsessive–compulsive disorder (Crossman, 2000; Fuxe et al., 2006; Ring and SerraMestres, 2002), and many of the addictions (Everitt and Robbins, 2005).”
Towards the neurobiology of emotional body language (2006, neutral): “The change from voluntary to more habitual and compulsive drug use represents a transition at the neural level from prefrontal cortical to striatal control over drug-seeking and drug-taking behaviour 81,82 .”
The cortico-basal ganglia integrative network: the role of the thalamus (2008, background): “Thus, in addition to their involvement in the expression of goal-directed behaviors through movement, the BG are also involved in the processes that lead to movement, including emotions, motivation, and cognition [12,52].”
Reward-Related Cortical Inputs Define a Large Striatal Region in Primates That Interface with Associative Cortical Connections, Providing a Substrate for Incentive-Based Learning (2006, background): “…internal capsule ; Pu , putamen nucleus . the rostral and dorsal striatal areas to synchronize different as - pects of reward and learning , making it a unique region for reward - based incentive drive to impact on long - term strategic planning and habit formation ( Everitt and Robbins , 2005 ) .”
Integrating psychological and neurobiological considerations regarding the development and maintenance of specific Internet-use disorders: An Interaction of Person-Affect-Cognition-Execution (I-PACE) model. (2016, neutral): “Due to conditioning processes in substance addictions, a generalization of situational features triggering cue-reactivity and craving is developed and the addictive behavior becomes habitual and/or compulsive (cf. Everitt, 2014; Everitt and Robbins, 2005, 2016).”
The Reward Circuit: Linking Primate Anatomy and Human Imaging (2010, background): “Indeed, cells in the dorsal striatum are progressively recruited during different types of learning from simple motor tasks to drug self-administration (Everitt and Robbins, 2005; Lehericy et al, 2005; Pasupathy and Miller, 2005; Porrino et al, 2004; Volkow et al, 2006).”
Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “…and decision making (i.e., prefrontal cortex) and in interoceptive processing (insular cortex) have been heavily implicated in drug addiction (Everitt et al., 2008; Fineberg et al., 2010; Koob and Volkow, 2010; Naqvi and Bechara, 2009), yet little is known of their precise role in compulsive…”
ΔFosB Induction in Orbitofrontal Cortex Mediates Tolerance to Cocaine-Induced Cognitive Dysfunction (2007, background): “Although much research to date has focused on understanding the reinforcing effects of addictive drugs (Everitt and Robbins, 2005), recent evidence indicates that cognitive changes caused by repeated drug intake are also important in the generation and maintenance of addiction and may determine…”
The glutamate homeostasis hypothesis of addiction (2009, background): “A corticostriatal circuitry of addiction A common perspective on addiction is that, with repeated drug use, drug-seeking behaviours become more habitual and less amenable to regulation by environmental contingencies, a viewpoint developed in recent review”
The role of the basal ganglia in habit formation (2006, background): “Everitt and Robbins have also shown that reafferent stimuli that predict reward can initially potentiate dopamine release in the accumbens, and eventually in the dorsal striatum, which suggests that these Pavlovian motivators can affect cortico-basal ganglia networks that mediate instrumental behavi”