Addiction: a disease of learning and memory.

By S. Hyman. American Journal of Psychiatry, 2005

886 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/994e725f82193eabb66cffb78c28e60fd3daa536

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Molecular Biology

Citations in the corpus

The Brain on Drugs: From Reward to Addiction. (2015, background): “These synaptic modifications generate a long-lasting molecular memory for the drug’s rewarding and conditioning effects that will modify subsequent behaviors (Hyman, 2005).”
Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective (2005, background): “The outline of these pharmacological systems given here is very simplistic, mainly because there are many excellent reviews that describe the molecular mechanisms by which neurotransmitters affect synaptic activity in addictive states and that explain how these activities influence cognitive systems”
The debate over dopamine’s role in reward: the case for incentive salience (2007, background): “A straightforward way for dopamine to cause reward learning would be simply to act as a UCS reinforcement signal that causally " stamps in " learned associations about preceding reward-related stimuli or responses when the UCS reinforcer occurs (Di Chiara 2002; Hyman 2005; Kelley 2004a; Wise 2004a).”
A unified framework for addiction: Vulnerabilities in the decision process (2008, background): “Addictive drugs have been hypothesized to drive maladaptive decision-making through pharmacological interactions with neurophysiological mechanisms evolved for normal learning systems (Berke 2003; Everitt et al. 2001; Hyman 2005; Kelley 2004a; Lowinson et al. 1997; Redish 2004).”
Extinction circuits for fear and addiction overlap in prefrontal cortex. (2009, background): “Addiction has been recognized as a disorder of learning and memory (Kelley 2004; Hyman 2005).”
The incentive sensitization theory of addiction: some current issues (2008, background): “(a) Incentive sensitization: more than just learning It has become popular to refer to addiction as a 'learning disorder' (Hyman 2005), but we think that this phrase may be too narrow to fit reality.”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, positive): “Considering the important roles of these brain regions, in particular the nucleus accumbens, striatum and prefrontal cortices, in addiction (Day and Carelli, 2007; Everitt and Robbins, 2005; Hyman, 2005; Hyman et al., 2006a; Jones and Bonci, 2005; Kalivas and Volkow, 2005; Kauer and Malenka, 2007; M”
Addiction as a complex social process: An action theoretical perspective (2008, background): “Conceptualizations of addiction stubbornly remain housed in the individual as an illness or disease (Hyman 2005; Reinarman 2005).”
REVIEW: Behavioural assessment of drug reinforcement and addictive features in rodents: an overview (2006, background): “Therefore, the actions of reinforcers should be understood in a broader context intimately related to learning and memory processes (White & Milner 1992; White 1996; Hyman 2005).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “…longterm memory (Di Chiara 1998, Berke & Hyman 2000, Hyman & Malenka 2001, Everitt & Wolf 2002, Robbins & Everitt 2002, Chao & Nestler 2004, Hyman 2005), namely by complex and bidirectional activity– dependent changes in the patterns and strength of excitatory synapses that utilize the…”
Prediction-error in the context of real social relationships modulates reward system activity (2012, background): “Other research notes that this intense affect bears semblance to addiction-related phenomenology (Aron et al., 2005; see also Ortigue and Bianchi-Demicheli, 2008) and may be intimately tied to reward system functions (Hyman, 2005).”
Stress enhances emotional memory-related theta oscillations in the medial temporal lobe (2021, background): “…the enhanced (emotional) memory formation under stress may have important implications for our understanding of stress-related mental disorders, such as anxiety disorders or posttraumatic stress disorder (PTSD; De Quervain et al., 2017; Pitman et al., 2012; Hyman, 2005; Dalgleish and Watts, 1990).”