The complex world of WNT receptor signalling

By Christof Niehrs. Nature reviews. Molecular cell biology, 2012

1,446 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f9e311819b7e36f24f071d4cf511adc52af02225

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Nusse
2. Hans Clevers
3. Shuhui Lim
4. D. Virshup
5. Philipp Kaldis

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Young Chul Kim
4. K. Guan
5. Fa-Xing Yu
6. Toshiro Moroishi
7. Z. Meng
8. H. Park

Citations in the corpus

• Mechanisms of intercellular Wnt transport (2019, neutral): “1B) (Niehrs, 2012).”
• Wnt/beta-catenin pathway: modulating anticancer immune response (2017, background): “WNTs (translated products of WNT gene) are cysteine-rich glycoproteins, secreted by cells into the extracellular matrix, that activate receptor-mediated signaling with cells in immediate proximity [10].”
• The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges (2019, background): “During EMT, cleavage of E-cadherin leads to the destabilization of adherens junctions and the release of β-catenin to function as a transcriptional activator for cell proliferation [61,62].”
• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “Taken altogether, a picture emerges of a complex extracellular landscape of Wnt-modifying and Wnt-binding factors, fine-tuning the strength of signaling (Niehrs, 2012).”
• Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities (2022, background): “The noncanonical Wnt pathways are independent of β-catenin-Tcell factor/lymphoid enhancer-binding factor (TCF/LEF), such as the Wnt/Ca pathway and noncanonical Wnt planar cell polarity.(2) The canonical Wnt pathway, also known as the Wnt/ β-catenin pathway, involves the nuclear translocation of β-ca”
• Cdks, cyclins and CKIs: roles beyond cell cycle regulation (2013, background): “However, in the presence of Wnt, the destruction complex is inactivated, and β-catenin accumulates and translocates into the nucleus where it acts as a co-activator for TCF/LEF-mediated transcription (Logan and Nusse, 2004; Niehrs, 2012).”
• Alternative Wnt Signaling Activates YAP/TAZ (2015, background): “See also Figure S2. ceptors can trigger alternative Wnt signaling pathways (Niehrs, 2012; Roman-Roman et al., 2004).”
• Structural basis of WLS/Evi-mediated Wnt transport and secretion (2020, background): “Ultimately, in a step which is again dependent on the presence of the O-palmitoleate, Wnts are delivered to Frizzled (FZD) and its associated coreceptors on the surface of the receiving cells to initiate downstream signaling (Niehrs, 2012; Yu et al., 2014).”