Wnt/beta-catenin pathway: modulating anticancer immune response

By S. Pai, B. Carneiro, J. M. Mota, R. Costa, C. A. Leite, R. Barroso-Sousa, J. Kaplan, Y. Chae, F. Giles. Journal of Hematology & Oncology, 2017

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Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/β-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/β-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bb49a74f228b09fecfb88f0cf57275df5b91dd18

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Citations in the corpus

Oncogenic Signaling Pathways in The Cancer Genome Atlas (2018, background): “…underway to develop therapies that target additional pathways, some of which are in clinical trials (Table S6) (Park and Guan, 2013), (Whitﬁeld et al., 2017), (Whitﬁeld et al., 2017), (Aster and Blacklow, 2012), (Takebe et al., 2014), (Buijs et al., 2012), (Sheen et al., 2013), (Pai et al., 2017).”