Alternative Wnt Signaling Activates YAP/TAZ
By H. Park, Young Chul Kim, Bo Yu, Toshiro Moroishi, Jung-Soon Mo, Steven W Plouffe, Z. Meng, Kimberly C. Lin, Fa-Xing Yu, C. Alexander and 2 more. Cell, 2015
666 citations recorded by the source corpus.
SUMMARY The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer. Here we discover YAP/TAZ as bona fide downstream effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3a induce YAP/TAZ activation independent of canonical Wnt/β-catenin signaling. Mechanistically, we delineate the ‘alternative Wnt-YAP/TAZ signaling axis’ that consists of Wnt - FZD/ROR - Gα12/13 - Rho GTPases -Lats1/2 to promote YAP/TAZ activation and TEAD-mediated transcription. YAP/TAZ mediate the biological functions of alternative Wnt signaling including gene expression, osteogenic differentiation, cell migration, and antagonism of Wnt/β-catenin signaling. Together, our work establishes YAP/TAZ as critical mediators of alternative Wnt signaling.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4c8325efe6011fd99eb9ea4fead67d1dd31e6bcb
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In Cell Biology
In Molecular Biology
- K. Guan
- S. Piccolo
- M. Cordenonsi
- Toshiro Moroishi
- Z. Meng
- F. Zanconato
- David M. Sabatini
- Michael N. Hall
Citations in the corpus
- Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments (2023, background): “Besides manchanotransduction, Wnt ligand-linked collagen culture is sufficient to induce YAP/TAZ activation and support cellular reprogramming [144], in accord with previous discovery of Wnt-YAP/TAZ pathway [145, 146].”
- Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. (2015, neutral): “However, a recent study suggests thatWnt activatesYAP/TAZ viaFrizzled (aGPCRlike Wnt receptor), Ga12/13, Rho GTPases, and LATS1/2 (Park et al., 2015).”
- Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? (2016, background): “Most recently, it has been demonstrated that YAP/TAZ could mediate alternative Wnt signaling-induced osteogenesis.(44) Animal studies showed that activation of Wnt signaling by overexpression of Wnt10b or supplementation of lithium could increase the thickness of trabecular bone.”
- Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model (2017, background): “Interestingly, Wnt5a/b-YAP signalling antagonises canonical Wnt/β-catenin signalling [31] and decreases expression of a panel of the major β-catenin/TCF target genes, including SOX9[31], which regulates genes related to cartilage ECM [32] and cartilage formation [33, 34].”
- Mechanisms of Hippo pathway regulation (2016, positive): “In Drosophila, the Tor pathway can regulate Yki’s ability to access its target genes in the nucleus (Parker and Struhl 2015).”
- YAP/TAZ at the roots of cancer (2016, background): “In line, YAP/TAZ are detected in the nucleus of most cells composing Wnt1-induced mammary tumors (Park et al., 2015; Serrano et al., 2013), and are largely upregulated and nuclear in colon adenomas of ApcMin/+ mice, and in the hyperplastic epithelium forming after conditional knockout of Apc in the ”