Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis.

By Anke Sparmann, D. Bar-Sagi. Cancer Cell, 2004

868 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f90c7382747014b604f9b62d12b94aa129f4c69f

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In Oncology

Citations in the corpus

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression (2010, background): “RASdriven tumors are also known to contain significant numbers of senescent cells (8), and these tumors are also highly vascularized (128).”
Senescence-messaging secretome: SMS-ing cellular stress (2009, background): “For instance, in the context of HRAS V12 -driven tumours, the HRAS-dependent increase in IL-8 expression is required for initiation of tumour-associated inflammation and neovascularizatio”
RAS oncogenes: weaving a tumorigenic web (2011, background): “Several cytokines have been implicated in this response, including interleukin-8 (IL-8), IL-6 and GRO1 (also known as CXCL1), and their RAS-dependent upregulation is predominantly mediated by the activation of signalling pathways that impinge on the transcriptional machinery controlling their expres”
NF-κB: linking inflammation and immunity to cancer development and progression (2005, background): “In a mouse xenograft model, RAS-induced CXCL8 production by transplanted cancer cells led to increased infiltration of inflammatory cell”
Four faces of cellular senescence (2011, neutral): “However, IL-6 and IL-8 have also been shown to promote malignant tumorigenesis in cooperation with certain activated oncogenes (Sparmann and Bar-Sagi, 2004; Ancrile et al., 2007).”
Inflammation, a Key Event in Cancer Development (2006, background): “CXCL-8 showed its role in the interaction between tumor cells and the host environment (119).”
Nuclear factor-κB in cancer development and progression (2006, background): “, whereas IL-8 (CXCL8) inhibition blocks the growth of a Ras-transformed human xenograft in these animal”
The tumour microenvironment as a target for chemoprevention (2007, background): “; recent data indicate that it can also have a key role in the progression of cance”
Immunity, Inflammation, and Cancer (2010, neutral): “…members, induce a transcriptional program that leads to remodeling of the tumor microenvironment through recruitment of leukocytes and lymphocytes, expression of tumor-promoting chemokines and cytokines, and induction of an angiogenic switch (Soucek et al., 2007; Sparmann and Bar-Sagi, 2004).”
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. (2008, background): “We consider it unlikely that the IL-6 (or IL-8) pools required for OIS (this paper), and for promoting oncogenicity (Sparmann and Bar-Sagi, 2004; Ancrile et al., 2007) or cell proliferation (this paper) are inherently different.”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “During inflammatory stimuli, Ras induces the expression of various inflammatory gene products, including the proinflammatory cytokines IL-1, IL-6, and IL-11 and the chemokine IL-8 [72].”
Neutrophils in the activation and regulation of innate and adaptive immunity (2011, background): “Indeed, activation of members of different classes of oncogenes results in the production of CXCL8 and related chemokine”
Tumor-associated neutrophils: new targets for cancer therapy. (2011, background): “Accordingly, simple neutrophil depletion experiments usingGr-1 antibodies have been shown to inhibit tumor growth (11), limitmetastasis number (12), and reduce endothelial cell recruitment to tumors (9).”