The tumour microenvironment as a target for chemoprevention

By A. Albini, M. Sporn. Nature Reviews. Cancer, 2007

841 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/13429928fba81831cbe241176a16b595de95c468

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Citations in the corpus

G protein-coupled receptors: novel targets for drug discovery in cancer (2010, background): “Such observations further support the concept that the complex interactions between cancer cells and stroma are attractive drug target”
Cancer as an overhealing wound: an old hypothesis revisited (2008, background): “Such treatments not only ameliorate chronic inflammatory disease but can also protect against certain cancers and/or reduce their progressio”
Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase (2008, background): “There is growing awareness that the tumour microenvironment has a key role in supporting tumour growth and in dictating the rules of host-tumour interaction [12,5].”
Cancer Evolution: Mathematical Models and Computational Inference (2014, background): “In addition, tumor cells are part of the so-called tumor microenvironment, a heterogeneous tissue containing not only cancer cells, but also stromal and immune cells (Albini and Sporn 2007).”
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy (2008, background): “of oxidative damage and cancer prevention before the accumulation of any genetic lesions at the early stage of carcinogenesis (36, 37).”
The myofibroblast: paradigm for a mechanically active cell. (2010, background): “The finding that cancer progression is stimulated by the myofibroblast-created environment has exposed the tumor-associated myofibroblast as an important target for anti-cancer therapy (Albini and Sporn, 2007).”
Stromal myofibroblasts are drivers of invasive cancer growth (2008, background): “Myofibroblasts have been proposed as putative targets for therapy.(2,5,64) The issue raised here is slightly different, discussing”
Modelling breast cancer: one size does not fit all (2007, background): “Thus, elucidating the mechanisms that regulate these interactions is critical and may yield new targets within the stromal environment for cancer therap”
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks (2011, background): “This microenvironment is composed of tumor-associated fibroblasts, endothelial cells, adipocytes, and immune cells, all of which have been shown to play a role in tumor growth and metastasis (6).”