Nuclear factor-κB in cancer development and progression

By M. Karin. Nature, 2006

2,877 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/769decf5a22b2081bced264e9b83187e7f805230

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Campisi
2. Zena Werb
3. M. Egeblad
4. E. Nakasone
5. M. Nieto
6. S. Shalapour
7. Michael R. Irwin
8. A. Mantovani

In Immunology

1. A. Mantovani
2. A. Sica
3. J. Campisi
4. M. Karin
5. M. Locati
6. Zena Werb
7. S. Shalapour
8. M. Egeblad

In Molecular Biology

1. J. Campisi
2. Zena Werb
3. E. Nakasone
4. M. Egeblad
5. E. White
6. Adam Freund
7. A. Sica
8. M. Karin

Citations in the corpus

• p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype (2011, background): “Both p38MAPK and ATM are required for NF-kB activity at senescence, and NF-kB requires simultaneous phosphorylation on multiple sites for its activity (Karin, 2006; Perkins, 2007).”
• Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. (2011, background): “Beyond its role in mediating inflammatory responses that can influence cancer progression via the microenvironment (Karin 2006), most studies suggest that the cell-intrinsic activities of NF-kB play a pro-oncogenic role during cancer progression, perhaps through regulating survival genes in cancers.”
• The molecular biology of head and neck cancer (2011, background): “, a transcription factor that provides an important survival signal to cells (for reviews on NF-κB see Ref”
• Inflammation and EMT: an alliance towards organ fibrosis and cancer progression (2009, background): “…kidney and also in cancer cells in general (see Box 1 and Fig 3) and the inflammation-mediated increase in NF-kB expression has been associated with several aspects of cancer development, mainly resistance to apoptosis and increased angiogenesis, with some connections to invasiveness (Karin, 2006).”
• Expression of microRNA-146 suppresses NF-κB activity with reduction of metastatic potential in breast cancer cells (2008, background): “Given that NF-κB activity is known to enhance the survival and metastatic potential of cancer cells (Karin, 2006; Van Waes, 2007; Sethi et al., 2008), the functional consequences of NFκB suppression in miR-146a/b-expressing MDA-MB-231 cells were explored using cell motility and Matrigel invasion ass”
• Why Sleep Is Important for Health: A Psychoneuroimmunology Perspective (2014, background): “Transcription factor binding motifs that were overrepresented in the sleep-deprivation condition included the promoters of genes involved in regulation by cyclic adenosine monophosphate/protein kinase A (cAMP/PKA)-induced transcription factors of the cAMP response element–binding protein/activating ”