NF-κB: linking inflammation and immunity to cancer development and progression

By M. Karin, F. Greten. Nature reviews. Immunology, 2005

2,086 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/e0428077a2d7c06309ede062f6b01f48de3618ea

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Citations in the corpus

Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. (2006, background): “Furthermore, recent experiments using specific ablation of a key player in the inflammatory response, NF-κB, in tumor-associated macrophages showed that this signaling pathway is important for tumor initiation and growth (Karin and Greten, 2005).”
Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “…at the induction of pro-survival pathways particularly mediated by NF-κB, STAT3 and other types of signaling (Dmitrieva-Posocco et al., 2019; Greten and Karin, 2005; Grivennikov et al., 2009), thereby increasing the survival probability of survival of transformed clone or enable proliferation.”
Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “Some of the properties of inflammation that contribute to these processes are understood, such as the promotion of angiogenesis (3), the induction of tumor-promoting cytokines (4), the up-regulation of antiapoptotic genes (5), and uncontrolled feed-forward signaling in tumor cells through cell surfa”
Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases (2008, positive): “…chemical, physical, mechanical, and psychological stress; high glucose; fatty acids; ultraviolet radiation; cigarette smoke; and other disease-causing factors (Aggarwal, 2004) (Kumar et al., 2004) (Sethi et al., 2008); (Tergaonkar, 2006) (Karin and Greten, 2005) (Ahn and Aggarwal, 2005).”
Luteolin, a flavonoid with potential for cancer prevention and therapy. (2008, background): “Because inflammation and its involved signaling pathways are strongly associated with carcinogenesis [64,65], luteolin's anti-inflammation role may contribute to cancer prevention.”
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer (2010, background): “A large body of evidence indicates that constitutive activation of NF-κB and chronic inflammation have a major role in tumour development and are seen in most tumour types, including leukaemia, lymphomas and solid tumour”
Involvement of linear polyubiquitylation of NEMO in NF-κB activation (2009, background): “NF-κB has crucial roles in many cellular functions through regulation of immune and inflammatory response”
Natural polyphenols: An overview (2017, background): “Furthermore, green tea consumption has been proposed to greatly reduce the cancer risk of the bile duct,([66]) bladder,([67]) breast,([68]) and colon.”