The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

By Jean-Philippe Coppé, P. Desprez, A. Krtolica, J. Campisi. Annual Review of Pathology, 2010

4,730 citations recorded by the source corpus.

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/dedcbb7d97cc5d7e0bdd079da30eaa936af73474

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Campisi
2. J. Kirkland
3. M. Demaria
4. T. Tchkonia
5. Adam Freund
6. Tuo Li
7. C. Patil
8. Jesús Gil

In Physiology

1. J. Campisi
2. Jesús Gil
3. M. Demaria
4. J. Kirkland
5. Adam Freund
6. T. Tchkonia
7. Alejandra Hernandez-Segura
8. J. Nehme

Citations in the corpus

• Aging, Cellular Senescence, and Cancer (2012, background): “Finally, the SASP also includes proteins that can help senescent cells evade immune recognition and clearance (92, 93).”
• A proteomic atlas of senescence-associated secretomes for aging biomarker development (2019, background): “Subsequently, numerous 78 unbiased gene expression studies performed on different tissues and donors of varying 79 ages suggest that the SASP is more complex and heterogeneous [23], however, a 80 recent meta-analysis of senescent cell transcriptomes confirmed the expression of a 81 few dozen origina”
• Mechanisms and functions of cellular senescence. (2018, neutral): “Senescent cells produce a complex mixture of soluble and insoluble factors that are collectively termed senescence-associated secretory phenotype (SASP) or senescence-messaging secretome (58, 59).”
• Hallmarks of Cellular Senescence. (2018, positive): “It is clear that the SASP has an important role in the pathophysiological activity of senescent cells, but it is too unspecific and heterogeneous to be used as an unequivocal marker for senescence [49,52].”
• LINE-1 derepression in senescent cells triggers interferon and inflammaging (2019, neutral): “Observed: qPCR was performed on 1 ng of genomic DNA and normalized to a known single copy locus. i , Activation of IFN-α and IFN-β 1 genes during senescence of WI-38 and IMR-90 cells was determined by RT-qPCR. j, Confirmation of the senescent status of cells in OIS (20 days, Fig.”
• Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “CCL-2 (MCP-1), CCL-20 (MIP-3 ), CCL-7 (MCP-3), CXCL-4 (PF-4), CXCL1 (Gro- ), and CXCL-12 (SDF-1) have been described in the SASP of cells undergoing to OIS and replicative senescence (72).”