Antioxidants Accelerate Lung Cancer Progression in Mice

By V. Sayin, Mohamed X Ibrahim, E. Larsson, J. Nilsson, P. Lindahl, M. Bergo. Science Translational Medicine, 2014

824 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f451334891162a6e9c06531cd73aa30ed4401f7a

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In Biochemistry

In Cancer Research

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Citations in the corpus

Mitochondrial metabolism and cancer (2017, background): “Conversely, in the presence of severe oxidative stress, ROS de facto inhibit metastatic dissemination, most likely as a direct consequence of reduced fitness and RCD or cellular senescence [159-161].”
Mitochondrial reactive oxygen species and cancer (2014, result): “In agreement with these results, in genetic mouse models of K-Ras- or B-Raf-induced lung cancer, treatment with NAC or vitamin E markedly enhanced tumor growth and accelerated mortality [98].”
Glutathione metabolism in cancer progression and treatment resistance (2018, background): “In addition to GSH, other common antioxidants, N-acetyl cysteine (NAC) and the vitamin E analogue trolox, promote distant metastasis (Carretero et al., 1999; Huang et al., 2001; Sayin et al., 2014).”
Glutathione: new roles in redox signaling for an old antioxidant (2014, background): “Moreover, it was reported that supplementing the diet with the antioxidants N-acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression (Sayin et al., 2014).”
The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, neutral): “tumors and at more advanced stages) [49].”
Oxidative Stress in Aging Human Skin (2015, neutral): “tumor formation [186].”
Torularhodin and Torulene: Bioproduction, Properties and Prospective Applications in Food and Cosmetics - a Review (2015, neutral): “Apparently antioxidant molecules reduce the expression of genes involved in the endogenous system of protection against free radicals, suppressing the signalization of tumor cells, allowing them to proliferate (Sayin et al. 2014).”